Dr Joaquin De Navascues
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Email
j.denavascues@essex.ac.uk -
Telephone
+44 (0) 1206 876585
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Location
3SW.3.10, Colchester Campus
Research and professional activities
Research interests
Molecular regulation of cell fate decisions
Stem cell-based adult tissue homeostasis
Late radiation toxicity
Conferences and presentations
Is the radiosensitivity of fruitflies clinically relevant?
Annual meeting of the Association for Radiation Research, Francis Crick Institute, London, 6/6/2022
Drosophila as a tool for radiobiology
Invited presentation, Drosophila gut meeting, University of Glasgow, Glasgow, 5/5/2022
Modelling late radiation toxicity to normal tissue in Drosophila
Invited presentation, Annual meeting of the Association for Radiation Research, (online), 13/7/2021
Modelling tissue-level responses to radiation in Drosophila
Invited presentation, Annual fly JEDI meeting, University of Essex, Colchester, United Kingdom, 16/9/2019
Teaching and supervision
Current teaching responsibilities
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Genetics and Evolution (BS102)
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Molecular Biology: Genes, Proteins and Disease (BS221)
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Research Project in Biomedical Science (BS831)
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Advanced Cancer Biology (BS932)
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Molecular Mechanisms of Disease (BS938)
Publications
Publications (1)
King, EA., Jacobsen, E., Woolner, N., de Navascués, J., Marshall, OJ. and Korzelius, J., (2024). The transcription factor Chronophage/BCL11A/B promotes intestinal stem cell proliferation and endocrine differentiation
Journal articles (10)
Guisoni, N., Martinez-Corral, R., Garcia-Ojalvo, J. and de Navascués, J., (2017). Diversity of fate outcomes in cell pairs under lateral inhibition. Development. 144 (7), 1177-1186
Fang, HY., Martinez-Arias, A. and de Navascués, J., (2016). Autocrine and paracrine Wingless signalling in the Drosophila midgut by both continuous gradient and asynchronous bursts of wingless expression. F1000Research. 5, 317-317
Porazinski, S., de Navascués, J., Yako, Y., Hill, W., Jones, MR., Maddison, R., Fujita, Y. and Hogan, C., (2016). EphA2 Drives the Segregation of Ras-Transformed Epithelial Cells from Normal Neighbors. Current Biology. 26 (23), 3220-3229
Jurado, J., de Navascués, J. and Gorfinkiel, N., (2016). α-Catenin stabilises Cadherin–Catenin complexes and modulates actomyosin dynamics to allow pulsatile apical contraction. Journal of Cell Science. 129 (24), 4496-4508
Guisoni, N., Martinez-Corral, R., Garcia Ojalvo, J. and de Navascués, J., (2015). Diversity of fate outcomes in cell pairs under lateral inhibition
de Navascués, J., Perdigoto, CN., Bian, Y., Schneider, MH., Bardin, AJ., Martínez-Arias, A. and Simons, BD., (2012). Drosophilamidgut homeostasis involves neutral competition between symmetrically dividing intestinal stem cells. The EMBO Journal. 31 (11), 2473-2485
Muñoz‐Descalzo, S., de Navascues, J. and Arias, AM., (2012). Wnt‐Notch signalling: An integrated mechanism regulating transitions between cell states. BioEssays. 34 (2), 110-118
de Navascués, J. and Modolell, J., (2010). The pronotum LIM-HD gene tailup is both a positive and a negative regulator of the proneural genes achaete and scute of Drosophila. Mechanisms of Development. 127 (9-12), 393-406
de Navascués, J. and Modolell, J., (2007). tailup, a LIM-HD gene, and Iro-C cooperate inDrosophiladorsal mesothorax specification. Development. 134 (9), 1779-1788
Villa-Cuesta, E., de Navascués, J., Ruiz-Gómez, M., del Corral, RD., Domínguez, M., de Celis, JF. and Modolell, J., (2003). Tufted Is a Gain-of-Function Allele That Promotes Ectopic Expression of the Proneural Gene amos in Drosophila. Genetics. 163 (4), 1403-1412
Grants and funding
2022
Advanced live imaging for the Eastern ARC with dual inverted light-sheets and AI-led analysis
Biotechnology and Biological Sciences Research Council
2021
Acquisition of the Drosophila model system to understand mechanisms of innate immunity regulation by chromatin dynamics
National Centre for the Replacement Refinement & Reduction of Animals in Research
2019
Molecular dynamics of a bHLH transcription factor network in stemness and bi-lineage differentiation in the intestine
The Royal Society
