Aleyna Guney
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Email
ag19966@essex.ac.uk -
Location
Colchester Campus
Profile
- TRAIL, Death receptor signalling
- Apoptotic Pathways
- Colorectal cancer
Biography
2019-2023 BSc Biomedical Science, University of Essex 2023-2024 MSD Molecular Medicine
Qualifications
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BSc Biomedical Science University of Essex (2023)
Research and professional activities
Thesis
The role of TRAIL-R2 signalling in the modulation chemotherapy-induced apoptosis pathways
Supervisor: Dr. Ralf Zwacka
Research interests
Apoptotic signalling pathways
Apoptotic Signaling Pathways in Colorectal Cancer Chemotherapy: I am investigating the mechanisms by which chemotherapy induces programmed cell death (apoptosis) in colorectal cancer. My research focuses on the two major pathways involved in apoptosis: (a) The intrinsic pathway, which is often associated with cellular stress and the role of the p53 tumor suppressor protein. (b) The extrinsic pathway, which involves death receptors such as TRAIL-R1, TRAIL-R2, and their ligand TRAIL.
Role of TRAIL-R2 in Chemotherapy-Induced Apoptosis
TNF-related apoptosis-inducing ligand receptor 2 (TRAIL-R2) is a a pro-apoptotic receptor found on the cell membrane. Since many cancer cells also express membrane death receptors, it presents a promising option for future therapeutic interventions. I am particularly interested in understanding the role of TRAIL-R2 in chemotherapy-induced apoptosis and its potential implications for conventional cancer treatment.
