Caitlin O'Shea
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Email
caitlin.oshea@essex.ac.uk -
Location
Colchester Campus
Profile
- Parkinson's Disease
- Motor Neurone Disease
- Targeted protein degradation
- Protein folding and misfolding
- Intrabodies
- Molecular biological techniques
Biography
Toxic misfolded proteins are central pathological hallmarks of neurodegenerative diseases, which are increasing in prevalence and carry a high financial and emotional burden. I am particularly interested in Parkinson's disease and amyotrophic lateral sclerosis. My research aim is to develop targeted protein degraders that clear these toxic proteins from the cell. My research also focuses on understanding proteostatic impairment in neurodegenerative diseases and maximising intracellular availability of novel therapeutic targeting domains called intrabodies.
Qualifications
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MSC Biomedical Science (Clinical Neuroscience) University of Plymouth (2022)
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BSc Biomedical Science University of Plymouth (2021)
Research and professional activities
Thesis
Developing targeted protein degradation therapies for neurodegenerative diseases
Supervisor: Gareth Wright , Leo Schalkwyk
