Email
preeves@essex.ac.ukTelephone
+44 (0) 1206 873763
Location
3SW.5.31, Colchester Campus
Biography
2005present. Lecturer, School of Biological Sciences, University of Essex, Colchester, UK. 1994-2005. Postdoctoral Research Fellow/Research Scientist, Department of Biology, MIT, Cambridge (USA). Laboratory of H. Gobind Khorana. 1991-1994. Postdoctoral Research Fellow, Department of Biological Sciences, University of Warwick, Coventry, UK. 1987-1991. PhD. in Molecular biology of protein secretion. University of Warwick.Coventry, UK.Supervisor George Salmond 1986-1987. Research Technician Department of Biological Sciences, University of Warwick, Coventry, UK. 1983-1986. BSc. (Hons) Microbiology and Microbial Technology. University of Warwick, Coventry, UK. Fellow of the Higher Education Authority (UK) Member of the Biochemical Society (UK) Member of the American Society for Biochemistry and Molecular Biology (USA) Research students: Mr Aidan Cooke- MPHD CELL AND MOLECULAR BIOLOGY Mr James Embling- MPHD BIOLOGICAL SCIENCES
Qualifications
BSc. (Upper 2nd class honours) Microbiology and Microbial Technology (Warwick)
PhD. Extracellular Enzyme Secretion in Erwinia (Warwick)
Post Graduate Certificate in Higher EducationPractice(Essex)
Research interests
Structural properties and activation mechanism of rhodopsin, the dim-light human photoreceptor (details)
Biosynthesis and cellular targeting of G-protein coupled receptors (GPCRs)
Development of gene expression systems for large-scale production and purification of membrane proteins (details)
Molecular mechanisms of Retinitis Pigmentosa caused by inherited mutations in rhodopsin
Current research
Molecular mechanism of vision losscaused byRetinitis Pigmentosa mutations in rhodopsin Funded by RP Fighting Blindness and Fight for Sight
Folding and activation mechanism(s) of the visual receptor rhodopsin. Funded by the National Institutes of Health (USA)
Current teaching responsibilities
Biomedical Science: Practice and Employability (BS214)
Mechanisms of Neurological Disease (BS350)
Research Project in Biomedical Science (BS831)
Gene Technology and Synthetic Biology (BS934)
Previous supervision
Degree subject: Biological Sciences
Degree type: Doctor of Philosophy
Awarded date: 20/3/2024
Degree subject: Cell and Molecular Biology
Degree type: Doctor of Philosophy
Awarded date: 20/4/2022
Degree subject: Molecular Medicine
Degree type: Master of Science (by Dissertation)
Awarded date: 27/7/2020
Degree subject: Cell and Molecular Biology
Degree type: Master of Science (by Dissertation)
Awarded date: 24/7/2020
Journal articles (62)
Reeves, PJ., (2023). Expression systems for bovine rhodopsin: a review of the progress made in the Khorana laboratory. Biophysical Reviews. 15 (1), 93-101
Grime, RL., Logan, RT., Nestorow, SA., Sridhar, P., Edwards, PC., Tate, CG., Klumperman, B., Dafforn, TR., Poyner, DR., Reeves, PJ. and Wheatley, M., (2021). Differences in SMA-like polymer architecture dictate the conformational changes exhibited by the membrane protein rhodopsin encapsulated in lipid nano-particles. Nanoscale. 13 (31), 13519-13528
Pope, AL., Sanchez-Reyes, OB., South, K., Zaitseva, E., Ziliox, M., Vogel, R., Reeves, PJ. and Smith, SO., (2020). A Conserved Proline Hinge Mediates Helix Dynamics and Activation of Rhodopsin. Structure. 28 (9), 1004-1013.e4
Athanasiou, D., Aguila, M., Bellingham, J., Li, W., McCulley, C., Reeves, PJ. and Cheetham, ME., (2018). The molecular and cellular basis of rhodopsin retinitis pigmentosa reveals potential strategies for therapy. Progress in Retinal and Eye Research. 62, 1-23
Athanasiou, D., Aguila, M., Opefi, CA., South, K., Bellingham, J., Bevilacqua, D., Munro, PM., Kanuga, N., Mackenzie, FE., Dubis, AM., Georgiadis, A., Graca, AB., Pearson, RA., Ali, RR., Sakami, S., Palczewski, K., Sherman, MY., Reeves, PJ. and Cheetham, ME., (2017). Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration. Human Molecular Genetics. 26 (2), 305-319
Sanchez-Reyes, OB., Cooke, ALG., Tranter, DB., Rashid, D., Eilers, M., Reeves, PJ. and Smith, SO., (2017). G Protein-Coupled Receptors Contain Two Conserved Packing Clusters. Biophysical Journal. 112 (11), 2315-2326
Kimata, N., Pope, A., Sanchez-Reyes, OB., Eilers, M., Opefi, CA., Ziliox, M., Reeves, PJ. and Smith, SO., (2016). Free backbone carbonyls mediate rhodopsin activation. Nature Structural and Molecular Biology. 23 (8), 738-743
Sandoval, A., Eichler, S., Madathil, S., Reeves, PJ., Fahmy, K. and Böckmann, RA., (2016). The Molecular Switching Mechanism at the Conserved D(E)RY Motif in Class-A GPCRs. Biophysical Journal. 111 (1), 79-89
Kimata, N., Pope, A., Eilers, M., Opefi, CA., Ziliox, M., Hirshfeld, A., Zaitseva, E., Vogel, R., Sheves, M., Reeves, PJ. and Smith, SO., (2016). Retinal orientation and interactions in rhodopsin reveal a two-stage trigger mechanism for activation. Nature Communications. 7 (1), 12683-
Kimata, N., Reeves, PJ. and Smith, SO., (2015). Uncovering the triggers for GPCR activation using solid-state NMR spectroscopy. Journal of Magnetic Resonance. 253, 111-118
Opefi, CA., Tranter, D., Smith, SO. and Reeves, PJ., (2015). Construction of Stable Mammalian Cell Lines for Inducible Expression of G Protein-Coupled Receptors. MEMBRANE PROTEINS - PRODUCTION AND FUNCTIONAL CHARACTERIZATION. 556, 283-305
Taddese, B., Upton, GJG., Bailey, GR., Jordan, SRD., Abdulla, NY., Reeves, PJ. and Reynolds, CA., (2014). Do Plants Contain G Protein-Coupled Receptors?. PLANT PHYSIOLOGY. 164 (1), 287-307
Chintapalli, SV., Illingworth, CJR., Upton, GJG., Sacquin-Mora, S., Reeves, PJ., Mohammedali, HS. and Reynolds, CA., (2014). Assessing the effect of dynamics on the closed-loop protein-folding hypothesis. Journal of The Royal Society Interface. 11 (91), 20130935-20130935
Pope, A., Eilers, M., Reeves, PJ. and Smith, SO., (2014). Amino acid conservation and interactions in rhodopsin: Probing receptor activation by NMR spectroscopy. Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1837 (5), 683-693
Vohra, S., Taddese, B., Conner, AC., Poyner, DR., Hay, DL., Barwell, J., Reeves, PJ., Upton, GJG. and Reynolds, CA., (2013). Similarity between class A and class B G-protein-coupled receptors exemplified through calcitonin gene-related peptide receptor modelling and mutagenesis studies. Journal of The Royal Society Interface. 10 (79), 20120846-20120846
Opefi, CA., South, K., Reynolds, CA., Smith, SO. and Reeves, PJ., (2013). Retinitis Pigmentosa Mutants Provide Insight into the Role of the N-terminal Cap in Rhodopsin Folding, Structure, and Function. Journal of Biological Chemistry. 288 (47), 33912-33926
Eilers, M., Goncalves, JA., Ahuja, S., Kirkup, C., Hirshfeld, A., Simmerling, C., Reeves, PJ., Sheves, M. and Smith, SO., (2012). Structural Transitions of Transmembrane Helix 6 in the Formation of Metarhodopsin I. The Journal of Physical Chemistry B. 116 (35), 10477-10489
Arakawa, M., Chakraborty, R., Upadhyaya, J., Eilers, M., Reeves, PJ., Smith, SO. and Chelikani, P., (2011). Structural and functional roles of small group-conserved amino acids present on helix-H7 in the β2-adrenergic receptor. Biochimica et Biophysica Acta (BBA) - Biomembranes. 1808 (4), 1170-1178
Chintapalli, SV., Yew, BK., Illingworth, CJR., Upton, GJG., Reeves, PJ., Parkes, KEB., Snell, CR. and Reynolds, CA., (2010). Closed loop folding units from structural alignments: Experimental foldons revisited. Journal of Computational Chemistry. 31 (15), 2689-2701
Goncalves, JA., South, K., Ahuja, S., Zaitseva, E., Opefi, CA., Eilers, M., Vogel, R., Reeves, PJ. and Smith, SO., (2010). Highly conserved tyrosine stabilizes the active state of rhodopsin. Proceedings of the National Academy of Sciences. 107 (46), 19861-19866
Hornak, V., Ahuja, S., Eilers, M., Goncalves, JA., Sheves, M., Reeves, PJ. and Smith, SO., (2010). Light Activation of Rhodopsin: Insights from Molecular Dynamics Simulations Guided by Solid-State NMR Distance Restraints. Journal of Molecular Biology. 396 (3), 510-527
Ahuja, S., Crocker, E., Eilers, M., Hornak, V., Hirshfeld, A., Ziliox, M., Syrett, N., Reeves, PJ., Khorana, HG., Sheves, M. and Smith, SO., (2009). Location of the Retinal Chromophore in the Activated State of Rhodopsin. Journal of Biological Chemistry. 284 (15), 10190-10201
Ahuja, S., Hornak, V., Yan, ECY., Syrett, N., Goncalves, JA., Hirshfeld, A., Ziliox, M., Sakmar, TP., Sheves, M., Reeves, PJ., Smith, SO. and Eilers, M., (2009). Helix movement is coupled to displacement of the second extracellular loop in rhodopsin activation. Nature Structural & Molecular Biology. 16 (2), 168-175
Takayama, H., Chelikani, P., Reeves, PJ., Zhang, S. and Khorana, HG., (2008). High-Level Expression, Single-Step Immunoaffinity Purification and Characterization of Human Tetraspanin Membrane Protein CD81. PLoS ONE. 3 (6), e2314-e2314
Vohra, S., Chintapalli, SV., Illingworth, CJR., Reeves, PJ., Mullineaux, PM., Clark, HSX., Dean, MK., Upton, GJG. and Reynolds, CA., (2007). Computational studies of Family A and Family B GPCRs. Biochemical Society Transactions. 35 (4), 749-754
Chelikani, P., Hornak, V., Eilers, M., Reeves, PJ., Smith, SO., RajBhandary, UL. and Khorana, HG., (2007). Role of group-conserved residues in the helical core of β 2 -adrenergic receptor. Proceedings of the National Academy of Sciences. 104 (17), 7027-7032
McKibbin, C., Farmer, NA., Jeans, C., Reeves, PJ., Khorana, HG., Wallace, BA., Edwards, PC., Villa, C. and Booth, PJ., (2007). Opsin Stability and Folding: Modulation by Phospholipid Bicelles. Journal of Molecular Biology. 374 (5), 1319-1332
McKibbin, C., Toye, AM., Reeves, PJ., Khorana, HG., Edwards, PC., Villa, C. and Booth, PJ., (2007). Opsin Stability and Folding: The Role of Cys185 and Abnormal Disulfide Bond Formation in the Intradiscal Domain. Journal of Molecular Biology. 374 (5), 1309-1318
Kota, P., Reeves, PJ., RajBhandary, UL. and Khorana, HG., (2006). Opsin is present as dimers in COS1 cells: Identification of amino acids at the dimeric interface. Proceedings of the National Academy of Sciences. 103 (9), 3054-3059
Chelikani, P., Reeves, PJ., Rajbhandary, UL. and Khorana, HG., (2006). The synthesis and high‐level expression of a β2‐adrenergic receptor gene in a tetracycline‐inducible stable mammalian cell line. Protein Science. 15 (6), 1433-1440
Zhao, X., Nagai, Y., Reeves, PJ., Kiley, P., Khorana, HG. and Zhang, S., (2006). Designer short peptide surfactants stabilize G protein-coupled receptor bovine rhodopsin. Proceedings of the National Academy of Sciences. 103 (47), 17707-17712
Patel, AB., Crocker, E., Reeves, PJ., Getmanova, EV., Eilers, M., Khorana, HG. and Smith, SO., (2005). Changes in Interhelical Hydrogen Bonding upon Rhodopsin Activation. Journal of Molecular Biology. 347 (4), 803-812
Kim, J-M., Hwa, J., Garriga, P., Reeves, PJ., RajBhandary, UL. and Khorana, HG., (2005). Light-Driven Activation of β2-Adrenergic Receptor Signaling by a Chimeric Rhodopsin Containing the β2-Adrenergic Receptor Cytoplasmic Loops. Biochemistry. 44 (7), 2284-2292
Klein-Seetharaman, J., Yanamala, NVK., Javeed, F., Reeves, PJ., Getmanova, EV., Loewen, MC., Schwalbe, H. and Khorana, HG., (2004). Differential dynamics in the G protein-coupled receptor rhodopsin revealed by solution NMR. Proceedings of the National Academy of Sciences. 101 (10), 3409-3413
Getmanova, E., Patel, AB., Klein-Seetharaman, J., Loewen, MC., Reeves, PJ., Friedman, N., Sheves, M., Smith, SO. and Khorana, HG., (2004). NMR Spectroscopy of Phosphorylated Wild-Type Rhodopsin: Mobility of the Phosphorylated C-Terminus of Rhodopsin in the Dark and upon Light Activation. Biochemistry. 43 (4), 1126-1133
Crocker, E., Patel, AB., Eilers, M., Jayaraman, S., Getmanova, E., Reeves, PJ., Ziliox, M., Khorana, HG., Sheves, M. and Smith, SO., (2004). Dipolar assisted rotational resonance NMR of tryptophan and tyrosine in rhodopsin. Journal of Biomolecular NMR. 29 (1), 11-20
Reeves, PJ., Callewaert, N., Contreras, R. and Khorana, HG., (2002). Structure and function in rhodopsin: High-level expression of rhodopsin with restricted and homogeneous N-glycosylation by a tetracycline-inducible N -acetylglucosaminyltransferase I-negative HEK293S stable mammalian cell line. Proceedings of the National Academy of Sciences. 99 (21), 13419-13424
Khorana, HG., Reeves, P. and Kim, J-M., (2002). Structure and Mechanism in G Protein-coupled Receptors. Pharmaceutical News. 9 (5), 287-294
Eilers, M., Ying, W., Reeves, PJ., Gobind Khorana, H. and Smith, SO., (2002). Magic angle spinning nuclear magnetic resonance of isotopically labeled rhodopsin. Methods in Enzymology. 343, 212-222
Reeves, PJ., Kim, J-M. and Khorana, HG., (2002). Structure and function in rhodopsin: A tetracycline-inducible system in stable mammalian cell lines for high-level expression of opsin mutants. Proceedings of the National Academy of Sciences. 99 (21), 13413-13418
Klein-Seetharaman, J., Reeves, PJ., Loewen, MC., Getmanova, EV., Chung, J., Schwalbe, H., Wright, PE. and Khorana, HG., (2002). Solution NMR spectroscopy of [α- 15 N]lysine-labeled rhodopsin: The single peak observed in both conventional and TROSY-type HSQC spectra is ascribed to Lys-339 in the carboxyl-terminal peptide sequence. Proceedings of the National Academy of Sciences. 99 (6), 3452-3457
Loewen, MC., Klein-Seetharaman, J., Getmanova, EV., Reeves, PJ., Schwalbe, H. and Khorana, HG., (2001). Solution 19 F nuclear Overhauser effects in structural studies of the cytoplasmic domain of mammalian rhodopsin. Proceedings of the National Academy of Sciences. 98 (9), 4888-4892
Cha, K., Reeves, PJ. and Khorana, HG., (2000). Structure and function in rhodopsin: Destabilization of rhodopsin by the binding of an antibody at the N-terminal segment provides support for involvement of the latter in an intradiscal tertiary structure. Proceedings of the National Academy of Sciences. 97 (7), 3016-3021
Bruel, C., Cha, K., Niu, L., Reeves, PJ. and Khorana, HG., (2000). Rhodopsin kinase: Two mAbs binding near the carboxyl terminus cause time-dependent inactivation. Proceedings of the National Academy of Sciences. 97 (7), 3010-3015
Bruel, C., Cha, K., Reeves, PJ., Getmanova, E. and Khorana, HG., (2000). Rhodopsin kinase: Expression in mammalian cells and a two-step purification. Proceedings of the National Academy of Sciences. 97 (7), 3004-3009
Hwa, J., Reeves, PJ., Klein-Seetharaman, J., Davidson, F. and Khorana, HG., (1999). Structure and function in rhodopsin: Further elucidation of the role of the intradiscal cysteines, Cys-110, -185, and -187, in rhodopsin folding and function. Proceedings of the National Academy of Sciences. 96 (5), 1932-1935
Reeves, PJ., Hwa, J. and Khorana, HG., (1999). Structure and function in rhodopsin: Kinetic studies of retinal binding to purified opsin mutants in defined phospholipid–detergent mixtures serve as probes of the retinal binding pocket. Proceedings of the National Academy of Sciences. 96 (5), 1927-1931
Eilers, M., Reeves, PJ., Ying, W., Khorana, HG. and Smith, SO., (1999). Magic angle spinning NMR of the protonated retinylidene Schiff base nitrogen in rhodopsin: Expression of 15 N-lysine- and 13 C-glycine-labeled opsin in a stable cell line. Proceedings of the National Academy of Sciences. 96 (2), 487-492
Klein-Seetharaman, J., Getmanova, EV., Loewen, MC., Reeves, PJ. and Khorana, HG., (1999). NMR spectroscopy in studies of light-induced structural changes in mammalian rhodopsin: Applicability of solution 19 F NMR. Proceedings of the National Academy of Sciences. 96 (24), 13744-13749
Housby, JN., Thomas, JD., Wharam, SD., Reeves, PJ. and Salmond, GPC., (1998). Conditional mutations in OutE and OutL block exoenzyme secretion across theErwinia carotovoraouter membrane. FEMS Microbiology Letters. 165 (1), 91-102
Reeves, PJ., Thurmond, RL. and Khorana, HG., (1997). High-level production of rhodopsin and selected mutants using stable mammalian cell lines. FASEB Journal. 11 (9)
Thomas, JD., Reeves, PJ. and Salmond, GPC., (1997). The general secretion pathway of Erwinia carotovora subsp. carotovora: analysis of the membrane topology of OutC and OutF. Microbiology. 143 (3), 713-720
Reeves, PJ., Thurmond, RL. and Khorana, HG., (1996). Structure and function in rhodopsin: high level expression of a synthetic bovine opsin gene and its mutants in stable mammalian cell lines.. Proceedings of the National Academy of Sciences. 93 (21), 11487-11492
Reeves, PJ., Douglas, P. and Salmond, GPC., (1994). Beta‐lactamase topology probe analysis of the OutO NMePhe peptidase, and six other Out protein components of the Erwinia carotovora general secretion pathway apparatus. Molecular Microbiology. 12 (3), 445-457
Walker, DS., (1994). The Major Secreted Cellulase, CelV,ofErwinia carotovorasubsp,carotovoraIs an Important Soft Rot Virulence Factor. Molecular Plant-Microbe Interactions. 7 (3), 425-425
Salmond, GPC. and Reeves, PJ., (1993). Membrance traffic wardens and protein secretion in Gram-negative bacteria. Trends in Biochemical Sciences. 18 (1), 7-12
Reeves, PJ., Whitcombe, D., Wharam, S., Gibson, M., Allison, G., Bunce, N., Barallon, R., Douglas, P., Mulholland, V., Stevens, S., Walker, D. and Salmond, GPC., (1993). Molecular cloning and characterization of 13 out genes from Erwinia carotovora subspecies carotovora: genes encoding members of a general secretion pathway (GSP) widespread in Gram‐negative bacteria. Molecular Microbiology. 8 (3), 443-456
Mulholland, V., Hinton, JCD., Sidebotham, J., Toth, IK., Hyman, LJ., Perombelon, MCM., Reeves, PJ. and Salmond, GPC., (1993). A pleiotropic reduced virulence (Rvi‐) mutant of Erwinia carotovora subspecies atroseptica is defective in flagella assembly proteins that are conserved in plant and animal bacterial pathogens. Molecular Microbiology. 10 (5), 1154-1154
Mulholland, V., Hinton, JCD., Sidebotham, J., Toth, IK., Hyman, LJ., Perombelon, MCM., Reeves, PJ. and Salmond, GPC., (1993). A pleiotropic reduced virulence (Rvi−) mutant of Erwinia carotovora subspecies atroseptica is defective in flagella assembly proteins that are conserved in plant and animal bacterial pathogens. Molecular Microbiology. 9 (2), 343-356
Jones, S., Yu, B., Bainton, NJ., Birdsall, M., Bycroft, BW., Chhabra, SR., Cox, AJ., Golby, P., Reeves, PJ. and Stephens, S., (1993). The lux autoinducer regulates the production of exoenzyme virulence determinants in Erwinia carotovora and Pseudomonas aeruginosa.. The EMBO Journal. 12 (6), 2477-2482
Swift, S., Winson, MK., Chan, PF., Bainton, NJ., Birdsall, M., Reeves, PJ., Rees, CED., Chhabra, SR., Hill, PJ., Throup, JP., Bycroft, BW., Salmond, GPC., Williams, P. and Stewart, GSAB., (1993). A novel strategy for the isolation of luxl homologues: evidence for the widespread distribution of a LuxR:Luxl superfamily in enteric bacteria. Molecular Microbiology. 10 (3), 511-520
Salmond, G. and Reeves, P., (1993). Response from Salmond and Reeves. Trends in Microbiology. 1 (7), 250-251
Book chapters (3)
Reeves, PJ., (2021). Construction of Recombinant Cell Lines for GPCR Expression. In: Methods in Molecular Biology. Springer US. 43- 60. 9781071612200
Kimata, N., Pope, A., Rashid, D., Reeves, PJ. and Smith, SO., (2015). Sequential Structural Changes in Rhodopsin Occurring upon Photoactivation. In: Methods in Molecular Biology. Springer New York. 159- 171. 9781493923298
Goncalves, J., Eilers, M., South, K., Opefi, CA., Laissue, PP., Reeves, PJ. and Smith, SO., (2013). Magic angle spinning nuclear magnetic resonance spectroscopy of G protein-coupled receptors. In: G Protein Coupled Receptors Modeling, Activation, Interactions and Virtual Screening. Editors: Conn, PM., . Elsevier. 365- 389. 9780124078659
Conferences (9)
Grime, RL., Logan, RT., Reeves, PJ. and Wheatley, M., (2020). Conformational dynamics of bovine rhodopsin in SMALPs, SMILPs, and DIBMALPs
Athanasiou, D., Pang, G., Bellingham, J., Aguila, M., Opefi, CA., Reeves, PJ. and Cheetham, ME., (2018). Pharmacological stimulation of the cell stress responses as a therapy for rhodopsin RP
Athanasiou, D., Aguila, M., South, K., Bevilacqua, D., Mackenzie, F., Munro, PM., Sherman, MY., Reeves, PJ. and Cheetham, ME., (2015). Improvement of P23H rod opsin traffic after metformin treatment accelerates the rate of retinal degeneration in P23H retinitis pigmentosa
Vickers, AJ., Ma, Y., Dudley, R., Reeves, PJ., Reynolds, CA. and Gadde, S., (2008). THz differential spectroscopy of Rhodopsin
Vickers, AJ., Dudley, R., Reeves, PJ., Reynolds, CA., Gadde, S., Nithyanand, TN. and Ma, Y., (2007). THz time-domain (THz-TDs) spectroscopy of bovine rhodopsin from rod outer segments
Vohra, S., Chintapalli, SV., Illingworth, CJR., Reeves, PJ., Mullineaux, PM., Clark, HSX., Dean, MK., Upton, GJG. and Reynolds, CA., (2007). Computational studies of Family A and Family B GPCRs
Vickers, AJ., Dudley, R., Reeves, PJ. and Ma, Y., (2006). Time-domain THz spectroscopy (TDS-THz) of bovine rhodopsin in solution
Reeves, PJ., Klein-Seetharaman, J., Getmanova, EV., Eilers, M., Loewen, MC., Smith, SO. and Khorana, HG., (1999). Expression and purification of rhodopsin and its mutants from stable mammalian cell lines: application to NMR studies
Thurmond, RL., Creuzenet, C., Reeves, PJ. and Khorana, HG., (1997). Structure and function in rhodopsin: Peptide sequences in the cytoplasmic loops of rhodopsin are intimately involved in interaction with rhodopsin kinase
2022
An In Vitro Model For Studies of Barnacle Cyprid Cementation
Office of Naval Research
2020
Development of an improved SMALP toolkit to extract active membrane proteins
Biotechnology and Biological Sciences Research Council
Replacement EPR spectrometer to the multiuser Biomedical EPR Facility at the University of Essex
Biotechnology and Biological Sciences Research Council
2019
Mechanisms of GPCR Signaling
National Institutes of Health
Mechanisms of GPCR Signaling
National Institutes of Health
2017
Biomedical Vacation Scholarships
Wellcome Trust
Measuring stress in the Endoplasmic Reticulum caused by rhodopsin retinitis pigmentosa mutants
Wellcome Trust
2015
Construction and Spectral Charaterisation of Rhodopsin Autosomal Dominant Retinitis Pigmentosa
Wellcome Trust
2014
Elucidation of Molecular Mechanism(s) of Retinitis Pigmentosa Resulting from Mutations in Rhodopson
Fight for Sight
Biomedical Vacation Scholarships - 2014 (Miss Stan)
Wellcome Trust
2012
Temperature-sensitive misfolding in Rhodopson Retinitis Pigmentosa mutants
Wellcome Trust
2011
Structural restoration of Rhodopsin ADRP mutants
BRPS
Vacation Scholarship: Modupe O Bakare
Wellcome Trust
Undergraduate Research Bursary - Jack Newman
Nuffield Foundation
Structure and Activation Mechanism of the Visual Pigment Rhodopsin
National Institute Of Health (Nih)
2010
Vacation Scholarship: Mang Ching Lai
Wellcome Trust
2009
Solid-State NMR Studies of Membrane Proteins & Coenzymes
The Research Foundation
