Professor Glyn Stanway
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Email
stanwg@essex.ac.uk -
Location
Colchester Campus
Profile
Biography
I joined the University 1986 as Lecturer in Molecular Genetics, after having done post-doctoral work in the Department of Medical Oncology, Charing Cross Hospital and the Department of Microbiology, University of Leicester. My PhD was done in the Chemistry Department, University College London. I take part in the activities of the European Study Group on the Molecular Biology of Picornaviruses, which organises the EUROPIC meetings. I am also a member of the ICTV Picornaviridae Study Group which reports on classification of picornaviruses. My research interests are centred on the molecular biology of medically important viruses. These include the enteroviruses which are a large group of RNA viruses and part of the Picornaviridae family. Important enteroviruses include the poliviruses, the causative agents of paralytic poliomyelitis, and coxsackieviruses which can cause a number of human diseases, including aseptic meningitis and heart disease. There is evidence that some enteroviruses can be the trigger for type 1 diabetes. My research interests also include the parechoviruses, which are increasingly being identified as important human pathogens of young children. All the work done in my laboratory is concerned with improving our understanding of how viruses replicate and cause disease and is intended to provide insights which may facilitate the design of effective vaccines or antivirus agents, as well as developing viruses as potential anti-cancer agents. We also have an active interest in virus taxonomy since understanding the relationship between viruses is important in identifying critical features which are central to replication.
Research and professional activities
Research interests
molecular virology of medically important picornaviruses, particularly coxsackievirus A9, parechoviruses and rhinoviruses
virus cell receptor interactions
RNA structures involved in replication
parechovirus and enterovirus molecular biology
Picornaviridae evolution and classification
translation and processing in picornaviruses
cell biology of virus infection
virotherapy of cancer
antivirus drugs
Teaching and supervision
Previous supervision
Degree subject: Molecular Medicine
Degree type: Doctor of Philosophy
Awarded date: 5/7/2021
Degree subject: Molecular Medicine
Degree type: Doctor of Philosophy
Awarded date: 29/6/2018
Degree subject: Biological Sciences
Degree type: Doctor of Philosophy
Awarded date: 11/5/2017
Degree subject: Biological Sciences
Degree type: Doctor of Philosophy
Awarded date: 5/4/2017
Degree subject: Microbiology
Degree type: Doctor of Philosophy
Awarded date: 15/2/2017
Degree subject: Biological Sciences
Degree type: Doctor of Philosophy
Awarded date: 22/9/2016
Degree subject: Molecular Medicine
Degree type: Doctor of Philosophy
Awarded date: 19/8/2016
Degree subject: Molecular Medicine: Medical Microbiology
Degree type: Doctor of Philosophy
Awarded date: 6/7/2016
Degree subject: Biological Sciences
Degree type: Doctor of Philosophy
Awarded date: 24/5/2016
Degree subject: Molecular Medicine
Degree type: Doctor of Philosophy
Awarded date: 7/3/2016
Degree subject: Molecular Medicine
Degree type: Doctor of Philosophy
Awarded date: 22/12/2015
Degree subject: Molecular Medicine
Degree type: Doctor of Philosophy
Awarded date: 14/1/2015
Degree subject: Molecular Medicine
Degree type: Doctor of Philosophy
Awarded date: 24/4/2014
Degree subject: Molecular Medicine
Degree type: Doctor of Philosophy
Awarded date: 6/7/2012
Publications
Journal articles (11)
Ioannou, M. and Stanway, G., (2021). Tropism of Coxsackie virus A9 depends on the +1 position of the RGD (arginine- glycine- aspartic acid) motif found at the C’ terminus of its VP1 capsid protein. Virus Research. 294, 198292-198292
Al-Zuhair, S., Ashraf, S., Hisaindee, S., Darmaki, NA., Battah, S., Svistunenko, D., Reeder, BJ., Stanway, G. and Chaudhary, A., (2017). Enzymatic pre-treatment of microalgae cells for enhanced extraction of proteins. Engineering in Life Sciences. 17 (2), 175-185
Oikarinen, S., Tauriainen, S., Hober, D., Lucas, B., Vazeou, A., Sioofy-Khojine, A., Bozas, E., Muir, P., Honkanen, H., Ilonen, J., Knip, M., Keskinen, P., Saha, M., Huhtala, H., Stanway, G., Bartsocas, C., Ludvigsson, J., Taylor, K. and Hyoty, H., (2014). Virus Antibody Survey in Different European Populations Indicates Risk Association Between Coxsackievirus B1 and Type 1 Diabetes. Diabetes. 63 (2), 655-662
McLeish, NJ., Williams, CH., Kaloudas, D., Roivainen, MM. and Stanway, G., (2012). Symmetry-related clustering of positive charges is a common mechanism for heparan sulfate binding in enteroviruses.. Journal of virology. 86 (20), 11163-70
Benschop, KSM., de Vries, M., Minnaar, RP., Stanway, G., van der Hoek, L., Wolthers, KC. and Simmonds, P., (2010). Comprehensive full-length sequence analyses of human parechoviruses: diversity and recombination. Journal of General Virology. 91 (Part 1), 145-154
Stanway, G. and Williams, CH., (2009). Enteroviruses and Diabetes. Journal of Medical Virology. 81 (1), creators-Stanway=3AGlyn=3A=3A
Williams, CH., Panayiotou, M., Girling, GD., Peard, CI., Oikarinen, S., Hyoty, H. and Stanway, G., (2009). Evolution and conservation in human parechovirus genomes. Journal of General Virology. 90 (7), 1702-1712
Heikkila, O., Susi, P., Stanway, G. and Hyypia, T., (2009). Integrin alpha V beta 6 is a high-affinity receptor for coxsackievirus A9. Journal of General Virology. 90 (1), 197-204
Williams, CH. and Stanway, G., (2009). Viruses: Genomes and Genomics. eLS
Le Gall, O., Christian, P., Fauquet, CM., King, AMQ., Knowles, NJ., Nakashima, N., Stanway, G. and Gorbalenya, AE., (2008). Picornavirales, a proposed order of positive-sense single-stranded RNA viruses with a pseudo-T=3 virion architecture. Archives Of Virology. 153 (4), 715-727
Benschop, KSM., Williams, CH., Wolthers, KC., Stanway, G. and Simmonds, P., (2008). Widespread recombination within human parechoviruses: analysis of temporal dynamics and constraints. Journal of General Virology. 89 (Part 4), 1030-1035