Dr Elizabeth Welbourn

Biography

2013 - present Senior lab technician in the metalloprotein research group of Dr Brandon Reeder and Dr Marcus Edwards. Work in the lab centres on globin research, currently developing a haemoglobin-based oxygen carrier. Other proteins used include Hells Gate haemoglobin, cytoglobin, androglobin and neuroglobin. 2007 - 2013 PhD in Biochemistry at University of Essex on the role of haemoglobin binding to cell membranes in cell damage in the body and blood storage. 1983 2005 chemistry teacher in secondary schools, including the role of Head of Department. Publications Reeder, Brandon and Deganutti, Giuseppe and Ukeri, John and Atanasio, Silvia and Svistunenko, Dimitri and Ronchetti, Christopher and Mobarec, Juan Carlos and Welbourn, Elizabeth and Asaju, Jeffrey and Vos, Marten and Wilson, Michael and Reynolds, Christopher (2024) The circularly permuted globin domain of Androglobin exhibits atypical heme stabilization and nitric oxide interaction. Chemical Science, 15 (18). pp. 6738-6751. DOI https://doi.org/10.1039/D4SC00953C Cooper, CE and Silkstone, GGA and Simons, M and Rajagopal, B and Syrett, N and Shaik, T and Gretton, S and Welbourn, E and Bülow, L and Eriksson, NL and Ronda, L and Mozzarelli, A and Eke, A and Mathe, D and Reeder, BJ (2019) Engineering tyrosine residues into hemoglobin enhances heme reduction, decreases oxidative stress and increases vascular retention of a hemoglobin based blood substitute. Free Radical Biology and Medicine, 134. pp. 106-118. DOI https://doi.org/10.1016/j.freeradbiomed.2018.12.030 Welbourn, Elizabeth M and Wilson, Michael T and Yusof, Ashril and Metodiev, Metodi V and Cooper, Chris E (2017) The mechanism of formation, structure and physiological relevance of covalent hemoglobin attachment to the erythrocyte membrane. Free Radical Biology and Medicine, 103. pp. 95-106. DOI https://doi.org/10.1016/j.freeradbiomed.2016.12.024

Qualifications

• Registered Scientist (RSci) Royal Society of Chemistry (2023)

• 2015 Accepted as Member of the Royal Society of Chemistry (2015)

• PhD in Biochemistry University of Essex (2013)

• BA Natural Sciences University of Cambridge (1982)