Francesca Wright
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Email
francesca.wright@essex.ac.uk -
Location
Colchester Campus
Profile
- TP53
- CRISPR
- Characterisation of Mutations
- Bayesian Networks as an Artificial Intelligence Agent
Qualifications
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BSc Chemistry with Medicinal Chemistry University of Warwick (2020)
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MSc Cancer Biology University of Essex (2022)
Research and professional activities
Thesis
TP53 Mutations as Causal Factors in Cancer and Telomerase Activation
We are analysing and characterising a novel nonsense p53 mutation. We have developed a new CRISPR-Select assay that uses purified Cas9 protein, to aid our characterisation. NGS results demonstrate that this novel mutation has been successfully introduced into a percentage of cells in culture. This provides the basis for a model to analyse mutations to oncogenes and tumour suppressors over time, which could be a powerful tool for cancer research.
Supervisor: Dr Metodi Metodiev , Dr Greg Brooke
