People

Francesca Wright

Graduate Laboratory Assistant
School of Life Sciences
Postgraduate Research Student
School of Life Sciences
 Francesca Wright

Profile

Ask me about
  • TP53
  • CRISPR
  • Characterisation of Mutations
  • Bayesian Networks as an Artificial Intelligence Agent

Qualifications

  • BSc Chemistry with Medicinal Chemistry University of Warwick (2020)

  • MSc Cancer Biology University of Essex (2022)

Research and professional activities

Thesis

TP53 Mutations as Causal Factors in Cancer and Telomerase Activation

We are analysing and characterising a novel nonsense p53 mutation. We have developed a new CRISPR-Select assay that uses purified Cas9 protein, to aid our characterisation. NGS results demonstrate that this novel mutation has been successfully introduced into a percentage of cells in culture. This provides the basis for a model to analyse mutations to oncogenes and tumour suppressors over time, which could be a powerful tool for cancer research.

Supervisor: Dr Metodi Metodiev , Dr Greg Brooke

Contact

fw21895@essex.ac.uk

Location:

Colchester Campus