Professor Vassiliy Bavro

Trampari, E., Zhang, C., Gotts, K., Savva, G., Bavro, V. and Webber, M., (2022). Cefotaxime Exposure Selects Mutations within the CA-Domain of envZ Which Promote Antibiotic Resistance but Repress Biofilm Formation in Salmonella. Microbiology Spectrum. 10 (3), e0214521-

Blair, JMA., Zeth, K., Bavro, VN. and Sancho-Vaello, E., (2022). The role of bacterial transport systems in the removal of host antimicrobial peptides in Gram-negative bacteria.. FEMS Microbiology Reviews. 46 (6), fuac032-fuac032

Souabni, H., dos Santos, WB., Cece, Q., Catoire, LJ., Puvanendran, D., Bavro, VN. and Picard, M., (2021). Quantitative real-time analysis of the efflux by the MacAB-TolC tripartite efflux pump clarifies the role of ATP hydrolysis within mechanotransmission mechanism. Communications Biology. 4 (1), 493-

Alav, I., Kobylka, J., Kuth, MS., Pos, KM., Picard, M., Blair, JMA. and Bavro, VN., (2021). Structure, Assembly, and Function of Tripartite Efflux and Type 1 Secretion Systems in Gram-Negative Bacteria. Chemical Reviews. 121 (9), 5479-5596

Alav, I., Bavro, VN. and Blair, JMA., (2021). Interchangeability of periplasmic adaptor proteins AcrA and AcrE in forming functional efflux pumps with AcrD in Salmonella enterica serovar Typhimurium. Journal of Antimicrobial Chemotherapy. 76 (10), 2558-2564

Moolla, N., Bailo, R., Marshall, R., Bavro, VN. and Bhatt, A., (2021). Structure-function analysis of MmpL7-mediated lipid transport in mycobacteria. The Cell Surface. 7, 100062-100062

Javid, A., Cooper, C., Singh, A., Schindler, S., Hänisch, M., Marshall, R., Kalscheuer, R., Bavro, VN. and Bhatt, A., (2020). The mycolic acid reductase Rv2509 has distinct structural motifs and is essential for growth in slow growing mycobacteria. Molecular Microbiology. 113 (2), 521-533

Domínguez-Medina, CC., Pérez-Toledo, M., Schager, AE., Marshall, JL., Cook, CN., Bobat, S., Hwang, H., Chun, BJ., Logan, E., Bryant, JA., Channell, WM., Morris, FC., Jossi, SE., Alshayea, A., Rossiter, AE., Barrow, PA., Horsnell, WG., MacLennan, CA., Henderson, IR., Lakey, JH., Gumbart, JC., López-Macías, C., Bavro, VN. and Cunningham, AF., (2020). Outer membrane protein size and LPS O-antigen define protective antibody targeting to the Salmonella surface. Nature Communications. 11 (1), 851-

Johnson, RM., Fais, C., Parmar, M., Cheruvara, H., Marshall, RL., Hesketh, SJ., Feasey, MC., Ruggerone, P., Vargiu, AV., Postis, VLG., Muench, SP. and Bavro, VN., (2020). Cryo-EM Structure and Molecular Dynamics Analysis of the Fluoroquinolone Resistant Mutant of the AcrB Transporter from Salmonella. Microorganisms. 8 (6), 943-943

Marshall, RL. and Bavro, VN., (2020). Mutations in the TolC periplasmic domain affect substrate specificity of the AcrAB-TolC pump. Frontiers in Molecular Biosciences. 7, 166-

Bryant, JA., Morris, FC., Knowles, TJ., Maderbocus, R., Heinz, E., Boelter, G., Alodaini, D., Colyer, A., Wotherspoon, PJ., Staunton, KA., Jeeves, M., Browning, DF., Sevastsyanovich, YR., Wells, TJ., Rossiter, AE., Bavro, VN., Sridhar, P., Ward, DG., Chong, Z-S., Goodall, ECA., Icke, C., Teo, A., Chng, S-S., Roper, DI., Lithgow, T., Cunningham, AF., Banzhaf, M., Overduin, M. and Henderson, IR., (2020). Structure of dual-BON domain protein DolP identifies phospholipid binding as a new mechanism for protein localization.. eLife. 9, 1-61

Conn, GL., Bavro, VN. and Davies, C., (2019). Editorial: Bacterial Mechanisms of Antibiotic Resistance: A Structural Perspective. Frontiers in Molecular Biosciences. 6, 71-

McNeil, HE., Alav, I., Corona Torres, R., Rossiter, AE., Laycock, E., Legood, S., Kaur, I., Davies, M., Wand, M., Webber, MA., Bavro, VN. and Blair, JMA., (2019). Identification of binding residues between periplasmic adapter protein (PAP) and RND efflux pumps explains PAP-pump promiscuity and roles in antimicrobial resistance.. PLoS Pathogens. 15 (12), e1008101-e1008101

Straw, ML., Chaplin, AK., Hough, MA., Paps, J., Bavro, VN., Wilson, MT., Vijgenboom, E. and Worrall, JAR., (2018). A cytosolic copper storage protein provides a second level of copper tolerance in Streptomyces lividans.. Metallomics: integrated biometal science. 2018 (10), 180-193

Lu, W-J., Lin, H-J., Janganan, TK., Li, C-Y., Chin, W-C., Bavro, VN. and Lin, H-TV., (2018). ATP-Binding Cassette Transporter VcaM from Vibrio cholerae is Dependent on the Outer Membrane Factor Family for Its Function.. International Journal of Molecular Sciences. 19 (4), 1000-1000

Abdullah, N., Kelly, JT., Graham, SC., Birch, J., Gonçalves-Carneiro, D., Mitchell, T., Thompson, RN., Lythgoe, KA., Logan, N., Hosie, MJ., Bavro, VN., Willett, BJ., Heaton, MP. and Bailey, D., (2018). Structure-Guided Identification of a Nonhuman Morbillivirus with Zoonotic Potential. Journal of Virology. 92 (23), e01248-e01218

Sen, H., Aggarwal, N., Ishionwu, C., Hussain, N., Parmar, C., Jamshad, M., Bavro, VN. and Lund, PA., (2017). Structural and functional analysis of the Escherichia coli acid-sensing histidine kinase EvgS. Journal of Bacteriology. 199 (18), e00310-e00317

Bavro, VN., Gupta, S. and Ralston, C., (2015). Oxidative footprinting in the study of structure and function of membrane proteins: Current state and perspectives. Biochemical Society Transactions. 43 (5), 983-994

Browning, DF., Bavro, VN., Mason, JL., Sevastsyanovich, YR., Rossiter, AE., Jeeves, M., Wells, TJ., Knowles, TJ., Cunningham, AF., Donald, JW., Palmer, T., Overduin, M. and Henderson, IR., (2015). Cross-species chimeras reveal BamA POTRA and β-barrel domains must be fine-tuned for efficient OMP insertion. Molecular Microbiology. 97 (4), 646-659

Zubcevic, L., Wang, S., Bavro, VN., Lee, S-J., Nichols, CG. and Tucker, SJ., (2015). Modular design of the selectivity filter pore loop in a novel family of prokaryotic inward rectifier' (NirBac) channels. Scientific Reports. 5 (1), 15305-

Bernardes, A., Textor, LC., Santos, JC., Cuadrado, NH., Kostetsky, EY., Roig, MG., Bavro, VN., Muniz, JRC., Shnyrov, VL. and Polikarpov, I., (2015). Crystal structure analysis of peroxidase from the palm tree Chamaerops excelsa. Biochimie. 111, 58-69

Blair, JMA., Bavro, VN., Ricci, V., Modi, N., Cacciotto, P., Kleinekathӧfer, U., Ruggerone, P., Vargiu, AV., Baylay, AJ., Smith, HE., Brandon, Y., Galloway, D. and Piddock, LJV., (2015). AcrB drug-binding pocket substitution confers clinically relevant resistance and altered substrate specificity.. Proceedings of the National Academy of Sciences. 112 (11), 3511-3516

Symmons, MF., Marshall, RL. and Bavro, VN., (2015). Architecture and roles of periplasmic adaptor proteins in tripartite efflux assemblies.. Frontiers in Microbiology. 6 (MAY), 513-

Weeks, JW., Bavro, VN. and Misra, R., (2014). Genetic assessment of the role of AcrB β-hairpins in the assembly of the TolC-AcrAB multidrug efflux pump of Escherichia coli.. Molecular Microbiology. 91 (5), 965-975

Zubcevic, L., Bavro, VN., Muniz, JRC., Schmidt, MR., Wang, S., De Zorzi, R., Venien-Bryan, C., Sansom, MSP., Nichols, CG. and Tucker, SJ., (2014). Control of KirBac3.1 potassium channel gating at the interface between cytoplasmic domains.. The Journal of Biological Chemistry. 289 (1), 143-151

Janganan, TK., Bavro, VN., Zhang, L., Borges‐Walmsley, MI. and Walmsley, AR., (2013). Tripartite efflux pumps: energy is required for dissociation, but not assembly or opening of the outer membrane channel of the pump. Molecular Microbiology. 88 (3), 590-602

Browning, DF., Matthews, SA., Rossiter, AE., Sevastsyanovich, YR., Jeeves, M., Mason, JL., Wells, TJ., Wardius, CA., Knowles, TJ., Cunningham, AF., Bavro, VN., Overduin, M. and Henderson, IR., (2013). Mutational and topological analysis of the Escherichia coli BamA protein.. PLoS One. 8 (12), e84512-e84512

Bavro, VN., De Zorzi, R., Schmidt, MR., Muniz, JRC., Zubcevic, L., Sansom, MSP., Vénien-Bryan, C. and Tucker, SJ., (2012). Structure of a KirBac potassium channel with an open bundle crossing indicates a mechanism of channel gating. Nature Structural & Molecular Biology. 19 (2), 158-163

Janganan, TK., Bavro, VN., Zhang, L., Matak-Vinkovic, D., Barrera, NP., Venien-Bryan, C., Robinson, CV., Borges-Walmsley, MI. and Walmsley, AR., (2011). Evidence for the assembly of a bacterial tripartite multidrug pump with a stoichiometry of 3:6:3.. The Journal of Biological Chemistry. 286 (30), 26900-26912

Janganan, TK., Zhang, L., Bavro, VN., Matak-Vinkovic, D., Barrera, NP., Burton, MF., Steel, PG., Robinson, CV., Borges-Walmsley, MI. and Walmsley, AR., (2011). Opening of the outer membrane protein channel in tripartite efflux pumps is induced by interaction with the membrane fusion partner.. The Journal of Biological Chemistry. 286 (7), 5484-5493

Wang, SC., Politis, A., Di Bartolo, N., Bavro, VN., Tucker, SJ., Booth, PJ., Barrera, NP. and Robinson, CV., (2010). Ion Mobility Mass Spectrometry of Two Tetrameric Membrane Protein Complexes Reveals Compact Structures and Differences in Stability and Packing. Journal of the American Chemical Society. 132 (44), 15468-15470

Gupta, S., Bavro, VN., D'Mello, R., Tucker, SJ., Vénien-Bryan, C. and Chance, MR., (2010). Conformational Changes During the Gating of a Potassium Channel Revealed by Structural Mass Spectrometry. Structure. 18 (7), 839-846

Paynter, JJ., Andres-Enguix, I., Fowler, PW., Tottey, S., Cheng, W., Enkvetchakul, D., Bavro, VN., Kusakabe, Y., Sansom, MSP., Robinson, NJ., Nichols, CG. and Tucker, SJ., (2010). Functional complementation and genetic deletion studies of KirBac channels: activatory mutations highlight gating-sensitive domains.. The Journal of Biological Chemistry. 285 (52), 40754-40761

Misra, R. and Bavro, VN., (2009). Assembly and transport mechanism of tripartite drug efflux systems. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1794 (5), 817-825

Barrera, NP., Isaacson, SC., Zhou, M., Bavro, VN., Welch, A., Schaedler, TA., Seeger, MA., Miguel, RN., Korkhov, VM., van Veen, HW., Venter, H., Walmsley, AR., Tate, CG. and Robinson, CV., (2009). Mass spectrometry of membrane transporters reveals subunit stoichiometry and interactions. Nature Methods. 6 (8), 585-587

Lin, HT., Bavro, VN., Barrera, NP., Frankish, HM., Velamakanni, S., van Veen, HW., Robinson, CV., Borges-Walmsley, MI. and Walmsley, AR., (2009). MacB ABC transporter is a dimer whose ATPase activity and macrolide-binding capacity are regulated by the membrane fusion protein MacA.. The Journal of Biological Chemistry. 284 (2), 1145-1154

Bavro, VN., Pietras, Z., Furnham, N., Pérez-Cano, L., Fernández-Recio, J., Pei, XY., Misra, R. and Luisi, B., (2008). Assembly and Channel Opening in a Bacterial Drug Efflux Machine. Molecular Cell. 30 (1), 114-121

Pietras, Z., Bavro, V., Furnham, N., Pellegrini-Calace, M., Milner-White, E. and Luisi, B., (2008). Structure and Mechanism of Drug Efflux Machinery in Gram Negative Bacteria. Current Drug Targets. 9 (9), 719-728

Worrall, JAR., Górna, M., Crump, NT., Phillips, LG., Tuck, AC., Price, AJ., Bavro, VN. and Luisi, BF., (2008). Reconstitution and analysis of the multienzyme Escherichia coli RNA degradosome.. Journal of Molecular Biology. 382 (4), 870-883

Mokrab, Y., Bavro, VN., Mizuguchi, K., Todorov, NP., Martin, IL., Dunn, SMJ., Chan, SL. and Chau, P-L., (2007). Exploring ligand recognition and ion flow in comparative models of the human GABA type A receptor. Journal of Molecular Graphics and Modelling. 26 (4), 760-774

Sola, M., Bavro, VN., Timmins, J., Franz, T., Ricard-Blum, S., Schoehn, G., Ruigrok, RWH., Paarmann, I., Saiyed, T., O'Sullivan, GA., Schmitt, B., Betz, H. and Weissenhorn, W., (2004). Structural basis of dynamic glycine receptor clustering by gephyrin. The EMBO Journal. 23 (13), 2510-2519

Fernandez-Recio, J., Walas, F., Federici, L., Venkatesh Pratap, J., Bavro, VN., Miguel, RN., Mizuguchi, K. and Luisi, B., (2004). A model of a transmembrane drug‐efflux pump from Gram‐negative bacteria. FEBS Letters. 578 (1-2), 5-9

Bavro, VN., Sola, M., Bracher, A., Kneussel, M., Betz, H. and Weissenhorn, W., (2002). Crystal structure of the GABA_A‐receptor‐associated protein, GABARAP. EMBO reports. 3 (2), 183-189

Gupta, S., D'Mello, R., Chance, MR., Bavro, VN., Venien-Bryan, C. and Tucker, SJ., (2010). Radiolytic Footprinting Reveals Conformational Changes During Potassium Channel Gating