Professor Leonard Schalkwyk

Flynn, R., Washer, S., Jeffries, AR., Andrayas, A., Shireby, G., Kumari, M., Schalkwyk, LC., Mill, J. and Hannon, E., (2022). Evaluation of nanopore sequencing for epigenetic epidemiology: a comparison with DNA methylation microarrays. Human Molecular Genetics. 31 (18), 3181-3190

Wang, Y., Gorrie-Stone, TJ., Grant, OA., Andrayas, AD., Zhai, X., McDonald-Maier, KD. and Schalkwyk, LC., (2022). InterpolatedXY: a two-step strategy to normalise DNA methylation microarray data avoiding sex bias. Bioinformatics. 38 (16), 3950-3957

Grant, OA., Wang, Y., Kumari, M., Zabet, NR. and Schalkwyk, L., (2022). Characterising sex differences of autosomal DNA methylation in whole blood using the Illumina EPIC array.. Clinical Epigenetics. 14 (1), 62-

Bao, Y., Gorrie-Stone, T., Hannon, E., Hughes, A., Andrayas, A., Neilson, G., Burrage, J., Mill, J., Schalkwyk, L. and Kumari, M., (2022). Social mobility across the lifecourse and DNA methylation age acceleration in adults in the UK.. Scientific Reports. 12 (1), 22284-22284

Smith, RG., Pishva, E., Shireby, G., Smith, AR., Roubroeks, JAY., Hannon, E., Wheildon, G., Mastroeni, D., Gasparoni, G., Riemenschneider, M., Giese, A., Sharp, AJ., Schalkwyk, L., Haroutunian, V., Viechtbauer, W., van den Hove, DLA., Weedon, M., Brokaw, D., Francis, PT., Thomas, AJ., Love, S., Morgan, K., Walter, J., Coleman, PD., Bennett, DA., De Jager, PL., Mill, J. and Lunnon, K., (2021). A meta-analysis of epigenome-wide association studies in Alzheimer's disease highlights novel differentially methylated loci across cortex.. Nature Communications. 12 (1), 3517-

Min, JL., Hemani, G., Kumari, M., Schalkwyk, LC. and et al, (2021). Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation. Nature Genetics. 53 (9), 1311-1321

Hannon, E., Dempster, EL., Mansell, G., Burrage, J., Bass, N., Bohlken, MM., Corvin, A., Curtis, CJ., Dempster, D., Di Forti, M., Dinan, TG., Donohoe, G., Gaughran, F., Gill, M., Gillespie, A., Gunasinghe, C., Hulshoff, HE., Hultman, CM., Johansson, V., Kahn, RS., Kaprio, J., Kenis, G., Kowalec, K., MacCabe, J., McDonald, C., McQuillin, A., Morris, DW., Murphy, KC., Mustard, CJ., Nenadic, I., O'Donovan, MC., Quattrone, D., Richards, AL., Rutten, BP., St Clair, D., Therman, S., Toulopoulou, T., Van Os, J., Waddington, JL., Wellcome Trust Case Control Consortium (WTCCC), CRESTAR consortium, Sullivan, P., Vassos, E., Breen, G., Collier, DA., Murray, RM., Schalkwyk, LS. and Mill, J., (2021). DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia.. eLife. 10, 1-53

Wang, Y., Hannon, E., Grant, O., Gorrie-Stone, T., Kumari, M., Mill, J., Zhai, X., McDonald-Maier, K. and Schalkwyk, L., (2021). DNA methylation-based sex classifier to predictsex and identify sex chromosome aneuploidy. BMC Genomics. 22 (1), 484-

Leung, SK., Jeffries, AR., Castanho, I., Jordan, BT., Moore, K., Davies, JP., Dempster, EL., Bray, NJ., O'Neill, P., Tseng, E., Ahmed, Z., Collier, DA., Jeffery, ED., Prabhakar, S., Schalkwyk, L., Jops, C., Gandal, MJ., Sheynkman, GM., Hannon, E. and Mill, J., (2021). Full-length transcript sequencing of human and mouse cerebral cortex identifies widespread isoform diversity and alternative splicing.. Cell Reports. 37 (7), 110022-110022

Åsenius, F., Gorrie-Stone, TJ., Brew, A., Panchbhaya, Y., Williamson, E., Schalkwyk, LC., Rakyan, VK., Holland, ML., Marzi, SJ. and Williams, DJ., (2020). The DNA methylome of human sperm is distinct from blood with little evidence for tissue-consistent obesity associations. PLoS Genetics. 16 (10), e1009035-e1009035

Shireby, GL., Davies, JP., Francis, PT., Burrage, J., Walker, EM., Neilson, GWA., Dahir, A., Thomas, AJ., Love, S., Smith, RG., Lunnon, K., Kumari, M., Schalkwyk, LC., Morgan, K., Brookes, K., Hannon, E. and Mill, J., (2020). Recalibrating the epigenetic clock: implications for assessing biological age in the human cortex.. Brain: a journal of neurology. 143 (12), 3763-3775

Åsenius, F., Gorrie-Stone, TJ., Brew, A., Panchbaya, Y., Williamson, E., Schalkwyk, LC., Rakyan, VK., Holland, ML., Marzi, SJ. and Williams, DJ., (2020). DNA methylation covariation in human whole blood and sperm: implications for studies of intergenerational epigenetic effects

Gorrie-Stone, TJ., Smart, MC., Saffari, A., Malki, K., Hannon, E., Burrage, J., Mill, J., Kumari, M. and Schalkwyk, LC., (2019). Bigmelon: tools for analysing large DNA methylation datasets. Bioinformatics. 35 (6), 981-986

Hannon, E., Marzi, SJ., Schalkwyk, LS. and Mill, J., (2019). Genetic risk variants for brain disorders are enriched in cortical H3K27ac domains. Molecular Brain. 12 (1), 7-

Hughes, A., Bao, Y., Smart, M., Gorrie-Stone, T., Hannon, E., Mill, J., Burrage, J., Schalkwyk, L. and Kumari, M., (2019). THE AUTHORS REPLY. American Journal of Epidemiology. 188 (2), 488-489

Mansell, G., Gorrie-Stone, TJ., Bao, Y., Kumari, M., Schalkwyk, LS., Mill, J. and Hannon, E., (2019). Guidance for DNA methylation studies: statistical insights from the Illumina EPIC array. BMC Genomics. 20 (1), 366-

Wong, CCY., Smith, RG., Hannon, E., Ramaswami, G., Parikshak, NN., Assary, E., Troakes, C., Poschmann, J., Schalkwyk, LC., Sun, W., Prabhakar, S., Geschwind, DH. and Mill, J., (2019). Genome-wide DNA methylation profiling identifies convergent molecular signatures associated with idiopathic and syndromic autism in post-mortem human brain tissue. Human Molecular Genetics. 28 (13), 2201-2211

Bell, CG., Lowe, R., Adams, PD., Baccarelli, AA., Beck, S., Bell, JT., Christensen, BC., Gladyshev, VN., Heijmans, BT., Horvath, S., Ideker, T., Issa, J-PJ., Kelsey, KT., Marioni, RE., Reik, W., Relton, CL., Schalkwyk, LC., Teschendorff, AE., Wagner, W., Zhang, K. and Rakyan, VK., (2019). DNA methylation aging clocks: challenges and recommendations. Genome Biology. 20 (1), 249-

El Khoury, LY., Gorrie-Stone, TJ., Smart, M., Hughes, A., Bao, Y., Andrayas, A., Burrage, J., Hannon, E., Kumari, M., Mill, J. and Schalkwyk, L., (2019). Systematic under-estimation of the epigenetic clock and age acceleration in older subjects. Genome Biology. 20 (1), 283-

Saffari, A., Arno, M., Nasser, E., Ronald, A., Wong, CCY., Schalkwyk, LC., Mill, J., Dudbridge, F. and Meaburn, EL., (2019). RNA sequencing of identical twins discordant for autism reveals blood-based signatures implicating immune and transcriptional dysregulation.. Molecular Autism. 10 (1), 38-38

Rutten, BPF., Vermetten, E., Vinkers, CH., Ursini, G., Daskalakis, NP., Pishva, E., de Nijs, L., Houtepen, LC., Eijssen, L., Jaffe, AE., Kenis, G., Viechtbauer, W., van den Hove, D., Schraut, KG., Lesch, K-P., Kleinman, JE., Hyde, TM., Weinberger, DR., Schalkwyk, L., Lunnon, K., Mill, J., Cohen, H., Yehuda, R., Baker, DG., Maihofer, AX., Nievergelt, CM., Geuze, E. and Boks, MPM., (2018). Longitudinal analyses of the DNA methylome in deployed military servicemen identify susceptibility loci for post-traumatic stress disorder. Molecular Psychiatry. 23 (5), 1145-1156

Smith, RG., Hannon, E., De Jager, PL., Chibnik, L., Lott, SJ., Condliffe, D., Smith, AR., Haroutunian, V., Troakes, C., Al-Sarraj, S., Bennett, DA., Powell, J., Lovestone, S., Schalkwyk, L., Mill, J. and Lunnon, K., (2018). Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology. Alzheimer's and Dementia. 14 (12), 1580-1588

Hughes, A., Smart, M., Gorrie-Stone, T., Hannon, E., Mill, J., Bao, Y., Burrage, J., Schalkwyk, L. and Kumari, M., (2018). Socioeconomic Position and DNA Methylation Age Acceleration across the Lifecourse.. American Journal of Epidemiology. 187 (11), 2346-2354

Hannon, E., Gorrie-Stone, TJ., Smart, MC., Burrage, J., Hughes, A., Bao, Y., Kumari, M., Schalkwyk, LC. and Mill, J., (2018). Leveraging DNA-Methylation Quantitative-Trait Loci to Characterize the Relationship between Methylomic Variation, Gene Expression, and Complex Traits. The American Journal of Human Genetics. 103 (5), 654-665

Marzi, SJ., Leung, SK., Ribarska, T., Hannon, E., Smith, AR., Pishva, E., Poschmann, J., Moore, K., Troakes, C., Al-Sarraj, S., Beck, S., Newman, S., Lunnon, K., Schalkwyk, LC. and Mill, J., (2018). A histone acetylome-wide association study of Alzheimer’s disease identifies disease-associated H3K27ac differences in the entorhinal cortex. Nature Neuroscience. 21 (11), 1618-1627

O’Brien, HE., Hannon, E., Hill, MJ., Toste, CC., Robertson, MJ., Morgan, JE., McLaughlin, G., Lewis, CM., Schalkwyk, LC., Hall, LS., Pardiñas, AF., Owen, MJ., O’Donovan, MC., Mill, J. and Bray, NJ., (2018). Expression quantitative trait loci in the developing human brain and their enrichment in neuropsychiatric disorders. Genome Biology. 19 (1), 194-

Viana, J., Hannon, E., Dempster, E., Pidsley, R., Macdonald, R., Knox, O., Spiers, H., Troakes, C., Al-Saraj, S., Turecki, G., Schalkwyk, LC. and Mill, J., (2017). Schizophrenia-associated methylomic variation: molecular signatures of disease and polygenic risk burden across multiple brain regions. Human Molecular Genetics. 26 (1), 210-225

Malki, K., Tosto, MG., Mouriño‐Talín, H., Rodríguez‐Lorenzo, S., Pain, O., Jumhaboy, I., Liu, T., Parpas, P., Newman, S., Malykh, A., Carboni, L., Uher, R., McGuffin, P., Schalkwyk, LC., Bryson, K. and Herbster, M., (2017). Highly polygenic architecture of antidepressant treatment response: Comparative analysis of SSRI and NRI treatment in an animal model of depression. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 174 (3), 235-250

Janecka, M., Marzi, SJ., Parsons, MJ., Liu, L., Paya-Cano, JL., Smith, RG., Fernandes, C. and Schalkwyk, LC., (2017). Genetic polymorphisms and their association with brain and behavioural measures in heterogeneous stock mice. Scientific Reports. 7 (1), 41204-

Janecka, M., Mill, J., Basson, MA., Goriely, A., Spiers, H., Reichenberg, A., Schalkwyk, LC. and Fernandes, C., (2017). Advanced paternal age effects in neurodevelopmental disorders?review of potential underlying mechanisms. Translational Psychiatry. 7 (1), e1019-e1019

Janecka, M., Haworth, CMA., Ronald, A., Krapohl, E., Happé, F., Mill, J., Schalkwyk, LC., Fernandes, C., Reichenberg, A. and Rijsdijk, F., (2017). Paternal Age Alters Social Development in Offspring. Journal of the American Academy of Child & Adolescent Psychiatry. 56 (5), 383-390

Lunnon, K., Keohane, A., Pidsley, R., Newhouse, S., Riddoch-Contreras, J., Thubron, EB., Devall, M., Soininen, H., Kłoszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Schalkwyk, L., Dobson, R., Malik, AN., Powell, J., Lovestone, S. and Hodges, A., (2017). Mitochondrial genes are altered in blood early in Alzheimer's disease. Neurobiology of Aging. 53, 36-47

Devall, M., Smith, RG., Jeffries, A., Hannon, E., Davies, MN., Schalkwyk, L., Mill, J., Weedon, M. and Lunnon, K., (2017). Regional differences in mitochondrial DNA methylation in human post-mortem brain tissue. Clinical Epigenetics. 9 (1), 47-

Spiers, H., Hannon, E., Schalkwyk, LC., Bray, NJ. and Mill, J., (2017). 5-hydroxymethylcytosine is highly dynamic across human fetal brain development. BMC Genomics. 18 (1), 738-

Smith, AR., Smith, RG., Condliffe, D., Hannon, E., Schalkwyk, L., Mill, J. and Lunnon, K., (2016). Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer's disease brain. Neurobiology of Aging. 47, 35-40

Hannon, E., Dempster, E., Viana, J., Burrage, J., Smith, AR., Macdonald, R., St Clair, D., Mustard, C., Breen, G., Therman, S., Kaprio, J., Toulopoulou, T., Pol, HEH., Bohlken, MM., Kahn, RS., Nenadic, I., Hultman, CM., Murray, RM., Collier, DA., Bass, N., Gurling, H., McQuillin, A., Schalkwyk, L. and Mill, J., (2016). An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation. Genome Biology. 17 (1), 176-

Lunnon, K., Hannon, E., Smith, RG., Dempster, E., Wong, C., Burrage, J., Troakes, C., Al-Sarraj, S., Kepa, A., Schalkwyk, L. and Mill, J., (2016). Variation in 5-hydroxymethylcytosine across human cortex and cerebellum. Genome Biology. 17 (1), 27-

Carter, KW., Carter, KW., Francis, RW., Bresnahan, M., Gissler, M., Grønborg, TK., Gross, R., Gunnes, N., Hammond, G., Hornig, M., Hultman, CM., Huttunen, J., Langridge, A., Leonard, H., Newman, S., Parner, ET., Petersson, G., Reichenberg, A., Sandin, S., Schendel, DE., Schalkwyk, L., Sourander, A., Steadman, C., Stoltenberg, C., Suominen, A., Surén, P., Susser, E., Sylvester Vethanayagam, A. and Yusof, Z., (2016). ViPAR: a software platform for the Virtual Pooling and Analysis of Research Data. International Journal of Epidemiology. 45 (2), 408-416

Malki, K., Du Rietz, E., Crusio, WE., Pain, O., Paya‐Cano, J., Karadaghi, RL., Sluyter, F., de Boer, SF., Sandnabba, K., Schalkwyk, LC., Asherson, P. and Tosto, MG., (2016). Transcriptome analysis of genes and gene networks involved in aggressive behavior in mouse and zebrafish. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 171 (6), 827-838

Houtepen, LC., Vinkers, CH., Carrillo-Roa, T., Hiemstra, M., Van Lier, PA., Meeus, W., Branje, S., Heim, CM., Nemeroff, CB., Mill, J., Schalkwyk, LC., Creyghton, MP., Kahn, RS., Joëls, M., Binder, EB. and Boks, MPM., (2016). Genome-wide DNA methylation levels and altered cortisol stress reactivity following childhood trauma in humans. Nature Communications. 7 (1), creators-Schalkwyk=3ALeonard_C=3A=3A

Hannon, E., Spiers, H., Viana, J., Pidsley, R., Burrage, J., Murphy, TM., Troakes, C., Turecki, G., O'Donovan, MC., Schalkwyk, LC., Bray, NJ. and Mill, J., (2016). Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci. Nature Neuroscience. 19 (1), 48-54

Malki, K., Tosto, MG., Pain, O., Sluyter, F., Mineur, YS., Crusio, WE., de Boer, S., Sandnabba, KN., Kesserwani, J., Robinson, E., Schalkwyk, LC. and Asherson, P., (2016). Comparative mRNA analysis of behavioral and genetic mouse models of aggression. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics. 171 (3), 427-436

Marzi, SJ., Meaburn, EL., Dempster, EL., Lunnon, K., Paya-Cano, JL., Smith, RG., Volta, M., Troakes, C., Schalkwyk, LC. and Mill, J., (2016). Tissue-specific patterns of allelically-skewed DNA methylation. Epigenetics. 11 (1), 24-35

Hannon, E., Lunnon, K., Schalkwyk, L. and Mill, J., (2015). Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes. Epigenetics. 10 (11), 1024-1032

Elliott, G., Hong, C., Xing, X., Zhou, X., Li, D., Coarfa, C., Bell, RJA., Maire, CL., Ligon, KL., Sigaroudinia, M., Gascard, P., Tlsty, TD., Harris, RA., Schalkwyk, LC., Bilenky, M., Mill, J., Farnham, PJ., Kellis, M., Marra, MA., Milosavljevic, A., Hirst, M., Stormo, GD., Wang, T. and Costello, JF., (2015). Intermediate DNA methylation is a conserved signature of genome regulation. Nature Communications. 6 (1), creators-Schalkwyk=3ALeonard_C=3A=3A

Janecka, M., Manduca, A., Servadio, M., Trezza, V., Smith, R., Mill, J., Schalkwyk, LC., Reichenberg, A. and Fernandes, C., (2015). Effects of advanced paternal age on trajectories of social behavior in offspring. Genes, Brain and Behavior. 14 (6), 443-453

Malki, K., Pain, O., Tosto, MG., Du Rietz, E., Carboni, L. and Schalkwyk, LC., (2015). Identification of genes and gene pathways associated with major depressive disorder by integrative brain analysis of rat and human prefrontal cortex transcriptomes. Translational Psychiatry. 5 (3), e519-e519

Martin, C., Tansey, KE., Schalkwyk, LC. and Powell, TR., (2015). The inflammatory cytokines: molecular biomarkers for major depressive disorder?. Biomarkers in Medicine. 9 (2), 169-180

Malki, K., Mineur, YS., Tosto, MG., Campbell, J., Karia, P., Jumabhoy, I., Sluyter, F., Crusio, WE. and Schalkwyk, LC., (2015). Pervasive and opposing effects of Unpredictable Chronic Mild Stress (UCMS) on hippocampal gene expression in BALB/cJ and C57BL/6J mouse strains. BMC Genomics. 16 (1), 262-

Spiers, H., Hannon, E., Schalkwyk, LC., Smith, R., Wong, CCY., O’Donovan, MC., Bray, NJ. and Mill, J., (2015). Methylomic trajectories across human fetal brain development. Genome Research. 25 (3), 338-352

Boks, MP., Mierlo, HCV., Rutten, BPF., Radstake, TRDJ., De Witte, L., Geuze, E., Horvath, S., Schalkwyk, LC., Vinkers, CH., Broen, JCA. and Vermetten, E., (2015). Longitudinal changes of telomere length and epigenetic age related to traumatic stress and post-traumatic stress disorder. Psychoneuroendocrinology. 51, 506-512

Ilott, NE., Schneider, T., Mill, J., Schalkwyk, L., Brolese, G., Bizarro, L., Stolerman, IP., Dempster, E. and Asherson, P., (2014). Long-term effects of gestational nicotine exposure and food-restriction on gene expression in the striatum of adolescent rats. PLoS ONE. 9 (2), creators-Schalkwyk=3ALeonard_C=3A=3A

Condliffe, D., Wong, A., Troakes, C., Proitsi, P., Patel, Y., Chouliaras, L., Fernandes, C., Cooper, J., Lovestone, S., Schalkwyk, L., Mill, J. and Lunnon, K., (2014). Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain. Neurobiology of Aging. 35 (8), 1850-1854

Viana, J., Pidsley, R., Troakes, C., Spiers, H., Wong, CCY., Al-Sarraj, S., Craig, I., Schalkwyk, L. and Mill, J., (2014). Epigenomic and transcriptomic signatures of a Klinefelter syndrome (47,XXY) karyotype in the brain. Epigenetics. 9 (4), 587-599

Bell, JT., Loomis, AK., Butcher, LM., Gao, F., Zhang, B., Hyde, CL., Sun, J., Wu, H., Ward, K., Harris, J., Scollen, S., Davies, MN., Schalkwyk, LC., Mill, J., Williams, FMK., Li, N., Deloukas, P., Beck, S., McMahon, SB., Wang, J., John, SL. and Spector, TD., (2014). Differential methylation of the TRPA1 promoter in pain sensitivity. Nature Communications. 5 (1), 2978-

Wong, CCY., Meaburn, EL., Ronald, A., Price, TS., Jeffries, AR., Schalkwyk, LC., Plomin, R. and Mill, J., (2014). Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits. Molecular Psychiatry. 19 (4), 495-503

Pidsley, R., Viana, J., Hannon, E., Spiers, H., Troakes, C., Al-saraj, S., Mechawar, N., Turecki, G., Schalkwyk, LC., Bray, NJ. and Mill, J., (2014). Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia. Genome Biology. 15 (10), creators-Schalkwyk=3ALeonard_C=3A=3A

Malki, K., Pain, O., Du Rietz, E., Tosto, MG., Paya-Cano, J., Sandnabba, KN., de Boer, S., Schalkwyk, LC. and Sluyter, F., (2014). Genes and Gene Networks Implicated in Aggression Related Behaviour. neurogenetics. 15 (4), 255-266

Powell, TR., McGuffin, P., D'Souza, UM., Cohen-Woods, S., Hosang, GM., Martin, C., Matthews, K., Day, RK., Farmer, AE., Tansey, KE. and Schalkwyk, LC., (2014). Putative transcriptomic biomarkers in the inflammatory cytokine pathway differentiate major depressive disorder patients from control subjects and bipolar disorder patients. PLoS ONE. 9 (3), creators-Schalkwyk=3ALeonard_C=3A=3A

Tarantino, LM. and Schalkwyk, LC., (2014). Introduction to mammalian genome special issue: genetics of behavior. Mammalian Genome. 25 (1-2), 1-2

Powell, TR., Powell‐Smith, G., Haddley, K., Mcguffin, P., Quinn, J., Schalkwyk, LC., Farmer, AE. and D'Souza, UM., (2014). Mood‐stabilizers differentially affect housekeeping gene expression in human cells. International Journal of Methods in Psychiatric Research. 23 (2), 279-288

Malki, K., Keers, R., Tosto, MG., Lourdusamy, A., Carboni, L., Domenici, E., Uher, R., McGuffin, P. and Schalkwyk, LC., (2014). The endogenous and reactive depression subtypes revisited: integrative animal and human studies implicate multiple distinct molecular mechanisms underlying major depressive disorder. BMC Medicine. 12 (1), 73-

Smith, RG., Fernandes, C., Kember, R., Schalkwyk, LC., Buxbaum, J., Reichenberg, A. and Mill, J., (2014). Transcriptomic changes in the frontal cortex associated with paternal age. Molecular Autism. 5 (1), creators-Schalkwyk=3ALeonard_C=3A=3A

Lunnon, K., Smith, R., Hannon, E., De Jager, PL., Srivastava, G., Volta, M., Troakes, C., Al-Sarraj, S., Burrage, J., Macdonald, R., Condliffe, D., Harries, LW., Katsel, P., Haroutunian, V., Kaminsky, Z., Joachim, C., Powell, J., Lovestone, S., Bennett, DA., Schalkwyk, LC. and Mill, J., (2014). Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease. Nature Neuroscience. 17 (9), 1164-1170

Punapart, M., Eltermaa, M., Oflijan, J., Sütt, S., Must, A., Kõks, S., Schalkwyk, LC., Fernandes, C., Vasar, E., Soomets, U. and Terasmaa, A., (2014). Effect of chronic valproic Acid treatment on hepatic gene expression profile in wfs1 knockout mouse. PPAR Research. 2014, 1-11

De Jager, PL., Srivastava, G., Lunnon, K., Burgess, J., Schalkwyk, LC., Yu, L., Eaton, ML., Keenan, BT., Ernst, J., McCabe, C., Tang, A., Raj, T., Replogle, J., Brodeur, W., Gabriel, S., Chai, HS., Younkin, C., Younkin, SG., Zou, F., Szyf, M., Epstein, CB., Schneider, JA., Bernstein, BE., Meissner, A., Ertekin-Taner, N., Chibnik, LB., Kellis, M., Mill, J. and Bennett, DA., (2014). Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci. Nature Neuroscience. 17 (9), 1156-1163

Davis, OSP., Band, G., Pirinen, M., Haworth, CMA., Meaburn, EL., Kovas, Y., Harlaar, N., Docherty, SJ., Hanscombe, KB., Trzaskowski, M., Curtis, CJC., Strange, A., Freeman, C., Bellenguez, C., Su, Z., Pearson, R., Vukcevic, D., Langford, C., Deloukas, P., Hunt, S., Gray, E., Dronov, S., Potter, SC., Tashakkori-Ghanbaria, A., Edkins, S., Bumpstead, SJ., Blackwell, JM., Bramon, E., Brown, MA., Casas, JP., Corvin, A., Duncanson, A., Jankowski, JAZ., Markus, HS., Mathew, CG., Palmer, CNA., Rautanen, A., Sawcer, SJ., Trembath, RC., Viswanathan, AC., Wood, NW., Barroso, I., Peltonen, L., Dale, PS., Petrill, SA., Schalkwyk, LS., Craig, IW., Lewis, CM., Price, TS., Donnelly, P., Plomin, R. and Spencer, CCA., (2014). The correlation between reading and mathematics ability at age twelve has a substantial genetic component. Nature Communications. 5 (1), creators-Schalkwyk=3ALeonard_C=3A=3A

Smith, RG., Reichenberg, A., Kember, RL., Buxbaum, JD., Schalkwyk, LC., Fernandes, C. and Mill, J., (2013). Advanced paternal age is associated with altered DNA methylation at brain-expressed imprinted loci in inbred mice: implications for neuropsychiatric disease. Molecular Psychiatry. 18 (6), 635-636

Powell, TR., Smith, RG., Hackinger, S., Schalkwyk, LC., Uher, R., McGuffin, P., Mill, J. and Tansey, KE., (2013). DNA methylation in interleukin-11 predicts clinical response to antidepressants in GENDEP. Translational Psychiatry. 3 (9), e300-e300

Powell, TR., Tansey, KE., Breen, G., Farmer, AE., Craig, IW., Uher, R., McGuffin, P., D’Souza, UM. and Schalkwyk, LC., (2013). ATP-binding cassette sub-family F member 1 (ABCF1) is identified as a putative therapeutic target of escitalopram in the inflammatory cytokine pathway. Journal of Psychopharmacology. 27 (7), 609-615

Pidsley, R., Wong, CCY., Volta, M., Lunnon, K., Mill, J. and Schalkwyk, LC., (2013). A data-driven approach to preprocessing Illumina 450K methylation array data. BMC Genomics. 14 (1), 293-

Powell, TR., Schalkwyk, LC., Heffernan, AL., Breen, G., Lawrence, T., Price, T., Farmer, AE., Aitchison, KJ., Craig, IW., Danese, A., Lewis, C., McGuffin, P., Uher, R., Tansey, KE. and D'Souza, UM., (2013). Tumor necrosis factor and its targets in the inflammatory cytokine pathway are identified as putative transcriptomic biomarkers for escitalopram response. European Neuropsychopharmacology. 23 (9), 1105-1114

Navarrete, K., Pedroso, I., De Jong, S., Stefansson, H., Steinberg, S., Stefansson, K., Ophoff, RA., Schalkwyk, LC. and Collier, DA., (2013). TCF4 (e2-2; ITF2): a schizophrenia-associated gene with pleiotropic effects on human disease. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics. 162 (1), 1-16

Malki, K., Tosto, MG., Jumabhoy, I., Lourdusamy, A., Sluyter, F., Craig, I., Uher, R., McGuffin, P. and Schalkwyk, LC., (2013). Integrative Mouse and Human mRNA Studies Using WGCNA Nominates Novel Candidate Genes Involved in the Pathogenesis of Major Depressive Disorder. Pharmacogenomics. 14 (16), 1979-1990

Lill, M., Kõks, S., Soomets, U., Schalkwyk, LC., Fernandes, C., Lutsar, I. and Taba, P., (2013). Peripheral blood RNA gene expression profiling in patients with bacterial meningitis. Frontiers in Neuroscience. 7 (7), 33-

Kõks, S., Overall, RW., Ivask, M., Soomets, U., Guha, M., Vasar, E., Fernandes, C. and Schalkwyk, LC., (2013). Silencing of theWFS1gene in HEK cells induces pathways related to neurodegeneration and mitochondrial damage. Physiological Genomics. 45 (5), 182-190

Kember, RL., Dempster, EL., Lee, THA., Schalkwyk, LC., Mill, J. and Fernandes, C., (2012). Maternal separation is associated with strain‐specific responses to stress and epigenetic alterations to Nr3c1, Avp, and Nr4a1 in mouse. Brain and Behavior. 2 (4), 455-467

Pidsley, R., Fernandes, C., Viana, J., Paya-Cano, JL., Liu, L., Smith, RG., Schalkwyk, LC. and Mill, J., (2012). DNA methylation at the Igf2/H19 imprinting control region is associated with cerebellum mass in outbred mice. Molecular Brain. 5 (1), 42-

Davies, MN., Volta, M., Pidsley, R., Lunnon, K., Dixit, A., Lovestone, S., Coarfa, C., Harris, RA., Milosavljevic, A., Troakes, C., Al-Sarraj, S., Dobson, R., Schalkwyk, LC. and Mill, J., (2012). Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood. Genome Biology. 13 (6), R43-

Jeffries, AR., Perfect, LW., Ledderose, J., Schalkwyk, LC., Bray, NJ., Mill, J. and Price, J., (2012). Stochastic Choice of Allelic Expression in Human Neural Stem Cells. Stem Cells. 30 (9), 1938-1947

Parsons, MJ., Grimm, C., Paya-Cano, J., Fernandes, C., Liu, L., Philip, VM., Chesler, EJ., Nietfeld, W., Lehrach, H. and Schalkwyk, LC., (2012). Genetic variation in hippocampal microRNA expression differences in C57BL/6 J X DBA/2 J (BXD) recombinant inbred mouse strains. BMC Genomics. 13 (1), 476-

Keers, R., Pedroso, I., Breen, G., Aitchison, KJ., Nolan, PM., Cichon, S., Nöthen, MM., Rietschel, M., Schalkwyk, LC. and Fernandes, C., (2012). Reduced anxiety and depression-like behaviours in the circadian period mutant mouse afterhours. PLoS ONE. 7 (6), creators-Schalkwyk=3ALeonard_C=3A=3A

Malki, K., Lourdusamy, A., Binder, E., Payá-Cano, J., Sluyter, F., Craig, I., Keers, R., McGuffin, P., Uher, R. and Schalkwyk, LC., (2012). Antidepressant-dependent mRNA changes in mouse associated with hippocampal neurogenesis in a mouse model of depression. Pharmacogenetics and Genomics. 22 (11), 765-776

Malki, K., Campbell, J., Davies, M., Keers, R., Uher, R., Ward, M., Paya‐Cano, J., Aitchinson, KJ., Binder, E., Sluyter, F., Kuhn, K., Selzer, S., Craig, I., McGuffin, P. and Schalkwyk, LC., (2012). Pharmacoproteomic investigation into antidepressant response in two mouse inbred strains. PROTEOMICS. 12 (14), 2355-2365

Dempster, EL., Pidsley, R., Schalkwyk, LC., Owens, S., Georgiades, A., Kane, F., Kalidindi, S., Picchioni, M., Kravariti, E., Toulopoulou, T., Murray, RM. and Mill, J., (2011). Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder. Human Molecular Genetics. 20 (24), 4786-4796

Kõks, S., Soomets, U., Plaas, M., Terasmaa, A., Noormets, K., Tillmann, V., Vasar, E., Fernandes, C. and Schalkwyk, LC., (2011). Hypothalamic gene expression profile indicates a reduction in G protein signaling in the Wfs1 mutant mice. Physiological Genomics. 43 (24), 1351-1358

Binder, E., Malki, K., Paya-Cano, JL., Fernandes, C., Aitchison, KJ., Mathé, AA., Sluyter, F. and Schalkwyk, LC., (2011). Antidepressants and the resilience to early-life stress in inbred mouse strains. Pharmacogenetics and Genomics. 21 (12), 779-789

Malki, K., Uher, R., Paya-Cano, J., Binder, E., Rietschel, M., Zobel, A., Mors, O., Hauser, J., Henigsberg, N., Jerman, B., Souery, D., Placentino, A., Ng, MY., Cohen-Woods, S., Sluyter, F., Farmer, A., Aitchison, KJ., Craig, IW., Lewis, CM., McGuffin, P. and Schalkwyk, LC., (2011). Convergent Animal and Human Evidence Suggests a Role of PPM1A Gene in Response to Antidepressants. Biological Psychiatry. 69 (4), 360-365

Sikk, K., (2011). Peripheral blood RNA expression profiling in illicit methcathinone users reveals effect on immune system. Frontiers in Genetics. 2 (AUG), 42-

Kember, RL., Fernandes, C., Tunbridge, EM., Liu, L., Payá‐Cano, JL., Parsons, MJ. and Schalkwyk, LC., (2010). A B2 SINE insertion in the Comt1 gene (Comt1^B2i) results in an overexpressing, behavior modifying allele present in classical inbred mouse strains. Genes, Brain and Behavior. 9 (8), 925-932

Docherty, SJ., Davis, OSP., Kovas, Y., Meaburn, EL., Dale, PS., Petrill, SA., Schalkwyk, LC. and Plomin, R., (2010). A genome‐wide association study identifies multiple loci associated with mathematics ability and disability. Genes, Brain and Behavior. 9 (2), 234-247

Kõks, S., Velthut, A., Sarapik, A., Altmäe, S., Reinmaa, E., Schalkwyk, LC., Fernandes, C., Lad, HV., Soomets, U., Jaakma, Ü. and Salumets, A., (2010). The differential transcriptome and ontology profiles of floating and cumulus granulosa cells in stimulated human antral follicles. MHR: Basic science of reproductive medicine. 16 (4), 229-240

Meaburn, EL., Schalkwyk, LC. and Mill, J., (2010). Allele-specific methylation in the human genome. Epigenetics. 5 (7), 578-582

Davies, MN., Meaburn, EL. and Schalkwyk, LC., (2010). Gene set enrichment; a problem of pathways. Briefings in Functional Genomics. 9 (5-6), 385-390

Schalkwyk, LC., Meaburn, EL., Smith, R., Dempster, EL., Jeffries, AR., Davies, MN., Plomin, R. and Mill, J., (2010). Allelic Skewing of DNA Methylation Is Widespread across the Genome. The American Journal of Human Genetics. 86 (2), 196-212

Davis, OSP., Butcher, LM., Docherty, SJ., Meaburn, EL., Curtis, CJC., Simpson, MA., Schalkwyk, LC. and Plomin, R., (2010). A Three-Stage Genome-Wide Association Study of General Cognitive Ability: Hunting the Small Effects. Behavior Genetics. 40 (6), 759-767

Lad, HV., Liu, L., Paya-Cano, JL., Parsons, MJ., Kember, R., Fernandes, C. and Schalkwyk, LC., (2010). Behavioural battery testing: Evaluation and behavioural outcomes in 8 inbred mouse strains. Physiology & Behavior. 99 (3), 301-316

Schosser, A., Pirlo, K., Gaysina, D., Cohen-Woods, S., Schalkwyk, LC., Elkin, A., Korszun, A., Gunasinghe, C., Gray, J., Jones, L., Meaburn, E., Farmer, AE., Craig, IW. and McGuffin, P., (2010). Utility of the pooling approach as applied to whole genome association scans with high-density Affymetrix microarrays. BMC Research Notes. 3 (1), 274-

Ronald, A., Butcher, LM., Docherty, S., Davis, OSP., Schalkwyk, LC., Craig, IW. and Plomin, R., (2010). A Genome-Wide Association Study of Social and Non-Social Autistic-Like Traits in the General Population Using Pooled DNA, 500 K SNP Microarrays and Both Community and Diagnosed Autism Replication Samples. Behavior Genetics. 40 (1), 31-45

Ronald, A., Butcher, LM., Docherty, SJ., Davis, OSP., Schalkwyk, LC., Craig, IW. and Plomin, R., (2010). Response to comment by Stuart Macgregor. Behavior Genetics. 40 (1), 48-48

Kõks, S., Soomets, U., Paya-Cano, JL., Fernandes, C., Luuk, H., Plaas, M., Terasmaa, A., Tillmann, V., Noormets, K., Vasar, E. and Schalkwyk, LC., (2009). Wfs1 gene deletion causes growth retardation in mice and interferes with the growth hormone pathway. Physiological Genomics. 37 (3), 249-259

Meaburn, EL., Fernandes, C., Craig, IW., Plomin, R. and Schalkwyk, LC., (2009). Assessing Individual Differences in Genome-Wide Gene Expression in Human Whole Blood: Reliability Over Four Hours and Stability Over 10 Months. Twin Research and Human Genetics. 12 (4), 372-380

Davis, OSP., Plomin, R. and Schalkwyk, LC., (2009). The SNPMaP package for R: a framework for genome-wide association using DNA pooling on microarrays. Bioinformatics. 25 (2), 281-283

Smith, RG., Kember, RL., Mill, J., Fernandes, C., Schalkwyk, LC., Buxbaum, JD. and Reichenberg, A., (2009). Advancing Paternal Age Is Associated with Deficits in Social and Exploratory Behaviors in the Offspring: A Mouse Model. PLoS ONE. 4 (12), e8456-e8456

Kas, MJH., Gelegen, C., Schalkwyk, LC. and Collier, DA., (2009). Interspecies Comparisons of Functional Genetic Variations and Their Implications in Neuropsychiatry. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics. 150B (3), 309-317

Overall, R., (2009). Genetics of the hippocampal transcriptome in mouse: a systematic survey and online neurogenomics resource. Frontiers in Neuroscience. 3 (NOV), 55-

Davies, MN., Lawn, S., Whatley, S., Fernandes, C., Williams, RW. and Schalkwyk, LC., (2009). To What Extent is Blood a Reasonable Surrogate for Brain in Gene Expression Studies: Estimation from Mouse Hippocampus and Spleen.. Frontiers in Neuroscience. 3 (OCT), 54-

Meaburn, EL., Harlaar, N., Craig, IW., Schalkwyk, LC. and Plomin, R., (2008). Quantitative trait locus association scan of early reading disability and ability using pooled DNA and 100K SNP microarrays in a sample of 5760 children. Molecular Psychiatry. 13 (7), 729-740

Kõks, S., Fernandes, C., Kurrikoff, K., Vasar, E. and Schalkwyk, LC., (2008). Gene expression profiling reveals upregulation of Tlr4 receptors in Cckb receptor deficient mice. Behavioural Brain Research. 188 (1), 62-70

Parsons, MJ., Grimm, CH., Paya-Cano, JL., Sugden, K., Nietfeld, W., Lehrach, H. and Schalkwyk, LC., (2008). Using hippocampal microRNA expression differences between mouse inbred strains to characterise miRNA function. Mammalian Genome. 19 (7-8), 552-560

Schalkwyk, LC., Fernandes, C., Nash, MW., Kurrikoff, K., Vasar, E. and Kõks, S., (2007). Interpretation of knockout experiments: the congenic footprint. Genes, Brain and Behavior. 6 (3), 299-303

Kas, MJH., Fernandes, C., Schalkwyk, LC. and Collier, DA., (2007). Genetics of behavioural domains across the neuropsychiatric spectrum; of mice and men. Molecular Psychiatry. 12 (4), 324-330

Lad, HV., Liu, L., Payá-Cano, JL., Fernandes, C. and Schalkwyk, LC., (2007). Quantitative traits for the tail suspension test: automation, optimization, and BXD RI mapping. Mammalian Genome. 18 (6-7), 482-491

Plomin, R. and Schalkwyk, LC., (2007). Microarrays. Developmental Science. 10 (1), 19-23

Caspi, A., Williams, B., Kim-Cohen, J., Craig, IW., Milne, BJ., Poulton, R., Schalkwyk, LC., Taylor, A., Werts, H. and Moffitt, TE., (2007). Moderation of breastfeeding effects on the IQ by genetic variation in fatty acid metabolism. Proceedings of the National Academy of Sciences. 104 (47), 18860-18865

Docherty, SJ., Butcher, LM., Schalkwyk, LC. and Plomin, R., (2007). Applicability of DNA pools on 500 KSNP microarrays for cost-effective initial screens in genomewide association studies. BMC Genomics. 8 (1), 214-214

Sugden, K., D'Souza, UM., Aitchison, KJ., Schalkwyk, LC., McGuffin, P., Byers, H., Campbell, J., Hye, A. and Pariante, CM., (2007). P.1.31 Gene expression analyses of mouse fibroblast cell line L929 after antidepressant treatment. European Neuropsychopharmacology. 17, S27-S28

Fernandes, C., Hoyle, E., Dempster, E., Schalkwyk, LC. and Collier, DA., (2006). Performance deficit of α7 nicotinic receptor knockout mice in a delayed matching‐to‐place task suggests a mild impairment of working/episodic‐like memory. Genes, Brain and Behavior. 5 (6), 433-440

Meaburn, E., Butcher, LM., Schalkwyk, LC. and Plomin, R., (2006). Genotyping pooled DNA using 100K SNP microarrays: A step towards genomewide association scans. Nucleic Acids Research. 34 (4), creators-Schalkwyk=3ALeonard_C=3A=3A

D'Souza, U., Sugden, K., Aitchison, KJ., Schalkwyk, LC., McGuffin, P. and Pariante, M., (2006). S.16.02 Depression: the GENDEP study. European Neuropsychopharmacology. 16, S187-S187

Galsworthy, MJ., Paya-Cano, JL., Liu, L., Monleón, S., Gregoryan, G., Fernandes, C., Schalkwyk, LC. and Plomin, R., (2005). Assessing Reliability, Heritability and General Cognitive Ability in a Battery of Cognitive Tasks for Laboratory Mice. Behavior Genetics. 35 (5), 675-692

Butcher, LM., Meaburn, E., Knight, J., Sham, PC., Schalkwyk, LC., Craig, IW. and Plomin, R., (2005). SNPs, microarrays and pooled DNA: identification of four loci associated with mild mental impairment in a sample of 6000 children. Human Molecular Genetics. 14 (10), 1315-1325

Butcher, LM., Meaburn, E., Dale, PS., Sham, P., Schalkwyk, LC., Craig, IW. and Plomin, R., (2005). Association analysis of mild mental impairment using DNA pooling to screen 432 brain-expressed single-nucleotide polymorphisms. Molecular Psychiatry. 10 (4), 384-392

Simpson, CL., Knight, J., Butcher, LM., Hansen, VK., Meaburn, EL., Schalkwyk, LC., Craig, IW., Powell, JF., Sham, PC. and Al-Chalabi, A., (2005). A central resource for accurate allele frequency estimation from pooled DNA genotyped on DNA microarrays. Nucleic Acids Research. 33 (3), e25-e25

Meaburn, E., Butcher, LM., Liu, L., Fernandes, C., Hansen, V., Al-Chalabi, A., Plomin, R., Craig, I. and Schalkwyk, LC., (2005). Genotyping DNA pools on microarrays: Tackling the QTL problem of large samples and large numbers of SNPs. BMC Genomics. 6 (1), creators-Schalkwyk=3ALeonard_C=3A=3A

Butcher, LM., Meaburn, E., Liu, L., Fernandes, C., Hill, L., Al-Chalabi, A., Plomin, R., Schalkwyk, L. and Craig, IW., (2004). Genotyping Pooled DNA on Microarrays: A Systematic Genome Screen of Thousands of SNPs in Large Samples to Detect QTLs for Complex Traits. Behavior Genetics. 34 (5), 549-555

Stolerman, IP., Chamberlain, S., Bizarro, L., Fernandes, C. and Schalkwyk, L., (2004). The role of nicotinic receptor α7 subunits in nicotine discrimination. Neuropharmacology. 46 (3), 363-371

Nyberg, J., Sandnabba, K., Schalkwyk, L. and Sluyter, F., (2004). Genetic and environmental (inter)actions in male mouse lines selected for aggressive and nonaggressive behavior. Genes, Brain and Behavior. 3 (2), 101-109

Fernandes, C., Liu, L., Paya-Cano, JL., Gregorov�, SA., Forejt, J. and Schalkwyk, LC., (2004). Behavioral Characterization of Wild Derived Male Mice (Mus musculus musculus) of the PWD/Ph Inbred Strain: High Exploration Compared to C57BL/6J. Behavior Genetics. 34 (6), 621-630

Fernandes, C., Paya‐Cano, JL., Sluyter, F., D'Souza, U., Plomin, R. and Schalkwyk, LC., (2004). Hippocampal gene expression profiling across eight mouse inbred strains: towards understanding the molecular basis for behaviour. European Journal of Neuroscience. 19 (9), 2576-2582

(2004). The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nature Genetics. 36 (11), 1133-1137

Ben Abdelkhalek, H., Beckers, A., Schuster-Gossler, K., Pavlova, MN., Burkhardt, H., Lickert, H., Rossant, J., Reinhardt, R., Schalkwyk, LC., Müller, I., Herrmann, BG., Ceolin, M., Rivera-Pomar, R. and Gossler, A., (2004). The mouse homeobox gene Not is required for caudal notochord development and affected by the truncate mutation. Genes & Development. 18 (14), 1725-1736

Craig, IW., Mill, J., Craig, GM., Loat, C. and Schalkwyk, LC., (2004). Application of microarrays to the analysis of the inactivation status of human X-linked genes expressed in lymphocytes. European Journal of Human Genetics. 12 (8), 639-646

Sluyter, F. and Schalkwyk, LC., (2003). Aggression across species. Behavior Genetics. 33 (5), 457-460

(2003). The nature and identification of quantitative trait loci: a community's view. Nature Reviews Genetics. 4 (11), 911-916

Mill, J., Galsworthy, MJ., Paya‐Cano, JL., Sluyter, F., Schalkwyk, LC., Plomin, R. and Asherson, P., (2002). Home‐cage activity in heterogeneous stock (HS) mice as a model of baseline activity. Genes, Brain and Behavior. 1 (3), 166-173

Klose, J., Nock, C., Herrmann, M., Stühler, K., Marcus, K., Blüggel, M., Krause, E., Schalkwyk, LC., Rastan, S., Brown, SDM., Büssow, K., Himmelbauer, H. and Lehrach, H., (2002). Genetic analysis of the mouse brain proteome. Nature Genetics. 30 (4), 385-393

Schalkwyk, LC., Cusack, B., Dunkel, I., Hopp, M., Kramer, M., Palczewski, S., Piefke, J., Scheel, S., Weiher, M., Wenske, G., Lehrach, H. and Himmelbauer, H., (2001). Advanced Integrated Mouse YAC Map Including BAC Framework. Genome Research. 11 (12), 2142-2150

Ryu, S., Cho, S., Park, S., Lim, W., Kim, M., Hong, S., Bae, D., Park, Y., Kim, B., Kim, H. and Yun, H., (2001). Cloning of the cel 9A gene and characterization of its gene product from marine bacterium Pseudomonas sp. SK38. Applied Microbiology and Biotechnology. 57 (1-2), 138-145

Leong, WL., Dobson, MJ., Logsdon, Jr., JM., Abdel-Majid, RM., Schalkwyk, LC., Guernsey, DL. and Neumann, PE., (2000). ETn insertion in the mouse Adcy1 gene: transcriptional and phylogenetic analyses. Mammalian Genome. 11 (2), 97-103

Gösele, C., Hong, L., Kreitler, T., Rossmann, M., Hieke, B., Groß, U., Kramer, M., Himmelbauer, H., Bihoreau, M-T., Kwitek-Black, AE., Twigger, S., Tonellato, PJ., Jacob, HJ., Schalkwyk, LC., Lindpaintner, K., Ganten, D., Lehrach, H. and Knoblauch, M., (2000). High-Throughput Scanning of the Rat Genome Using Interspersed Repetitive Sequence-PCR Markers. Genomics. 69 (3), 287-294

Knoblauch, M., Gösele, C., Zimdahl, H., Hieke, B., Himmelbauer, H., Schalkwyk, L., Lindpaintner, K., Ganten, D. and Lehrach, H., (2000). New tools for the high throughput characterization of rat genomic DNA samples. Journal of Experimental Animal Science. 41 (1-2), 35-37

Himmelbauer, H., (2000). Interspersed repetitive sequence (IRS)-PCR for typing of whole genome radiation hybrid panels. Nucleic Acids Research. 28 (2), 7e-7

Zhu, B., Smith, JA., Tracey, SM., Konfortov, BA., Welzel, K., Schalkwyk, LC., Lehrach, H., Kollers, S., Masabanda, J., Buitkamp, J., Fries, R., Williams, JL. and Miller, JR., (1999). A 5× genome coverage bovine BAC library: production, characterization, and distribution. Mammalian Genome. 10 (7), 706-709

Hills, D., Tracey, S., Masabanda, J., Fries, R., Schalkwyk, LC., Lehrach, H., Miller, JR. and Williams, JL., (1999). A bovine YAC library containing four- to five-fold genome equivalents. Mammalian Genome. 10 (8), 837-838

Nock, C., Gauss, C., Schalkwyk, LC., Klose, J., Lehrach, H. and Himmelbauer, H., (1999). Technology development at the interface of proteome research and genomics: Mapping nonpolymorphic proteins on the physical map of mouse chromosomes. Electrophoresis. 20 (4-5), 1027-1032

Nock, C., Gauss, C., Schalkwyk, LC., Klose, J., Lehrach, H. and Himmelbauer, H., (1999). Technology development at the interface of proteome research and genomics: Mapping nonpolymorphic proteins on the physical map of mouse chromosomes. Electrophoresis. 20 (4-5), 1027-1032

Schalkwyk, LC., Jung, M., Daser, A., Weiher, M., Walter, J., Himmelbauer, H. and Lehrach, H., (1999). Panel of Microsatellite Markers for Whole-Genome Scans and Radiation Hybrid Mapping and a Mouse Family Tree. Genome Research. 9 (9), 878-887

Schalkwyk, LC., Himmelbauer, H. and Lehrach, H., (1999). Toward the mammalian transcript map. Archiv fur Tierzucht. 42 (6 SUPPL.), 67-73

Buitkamp, J., Ewald, D., Schalkwyk, L., Weiher, M., Masabanda, J., Sazanov, A., Lehrach, H. and Fries, R., (1998). Construction and characterisation of a gridded chicken cosmid library with four‐fold genomic coverage. Animal Genetics. 29 (4), 295-301

Priestley, A., (1998). Molecular and biochemical characterisation of DNA-dependent protein kinase-defective rodent mutant irs-20. Nucleic Acids Research. 26 (8), 1965-1973

Schalkwyk, LC., Weiher, M., Kirby, M., Cusack, B., Himmelbauer, H. and Lehrach, H., (1998). Refined radiation hybrid map of mouse Chromosome 17. Mammalian Genome. 9 (10), 807-811

Himmelbauer, H., Wedemeyer, N., Haaf, T., Wanker, EE., Schalkwyk, LC. and Lehrach, H., (1998). IRS-PCR-based genetic mapping of the huntingtin interacting protein gene (HIP1) on mouse Chromosome 5. Mammalian Genome. 9 (1), 26-31

Himmelbauer, H., Dunkel, I., Otto, GW., Burgtorf, C., Schalkwyk, LC. and Lehrach, H., (1998). Complex probes for high-throughput parallel genetic mapping of genomic mouse BAC clones. Mammalian Genome. 9 (8), 611-616

Abdel-Majid, RM., Leong, WL., Schalkwyk, LC., Smallman, DS., Wong, ST., Storm, DR., Fine, A., Dobson, MJ., Guernsey, DL. and Neumann, PE., (1998). Loss of adenylyl cyclase I activity disrupts patterning of mouse somatosensory cortex. Nature Genetics. 19 (3), 289-291

Toye, AA., Schalkwyk, L., Lehrach, H. and Bumstead, N., (1997). A yeast artificial chromosome (YAC) library containing 10 haploid chicken genome equivalents. Mammalian Genome. 8 (4), 274-276

Crnogorac-Jurcevic, T., Brown, JR., Lehrach, H. and Schalkwyk, LC., (1997). Tetraodon fluviatilis,a New Puffer Fish Model for Genome Studies. Genomics. 41 (2), 177-184

Cai, L., Schalkwyk, LC., Schoeberlein-Stehli, A., Zee, RYL., Smith, A., Haaf, T., Georges, M., Lehrach, H. and Lindpaintner, K., (1997). Construction and Characterization of a 10-Genome Equivalent Yeast Artificial Chromosome Library for the Laboratory Rat,Rattus norvegicus. Genomics. 39 (3), 385-392

Hunter, KW., Riba, L., Schalkwyk, L., Clark, M., Resenchuk, S., Beeghly, A., Su, J., Tinkov, F., Lee, P., Ramu, E., Lehrach, H. and Housman, D., (1996). Toward the construction of integrated physical and genetic maps of the mouse genome using interspersed repetitive sequence PCR (IRS-PCR) genomics.. Genome Research. 6 (4), 290-299

McCarthy, L., Hunter, K., Schalkwyk, L., Riba, L., Anson, S., Mott, R., Newell, W., Bruley, C., Bar, I. and Ramu, E., (1995). Efficient high-resolution genetic mapping of mouse interspersed repetitive sequence PCR products, toward integrated genetic and physical mapping of the mouse genome.. Proceedings of the National Academy of Sciences. 92 (12), 5302-5306

Schalkwyk, LC., Francis, F. and Lehrach, H., (1995). Techniques in mammalian genome mapping. Current Opinion in Biotechnology. 6 (1), 37-43

Breen, M., Deakin, L., Macdonald, B., Miller, S., Sibson, R., Tarttelin, E., Avner, P., Bourgade, F., Guenet, JL., Montagutelli, X., Poirier, C., Simon, D., Tailor, D., Bishop, M., Kelly, M., Rysavy, F., Rastan, S., Norris, D., Shepherd, D., Abbott, C., Pilz, A., Hodge, S., Jackson, I., Boyd, Y., Blair, H., Maslen, G., Todd, JA., Reed, PW., Stoye, J., Ashworth, A., McCarthy, L., Cox, R., Schalkwyk, LC., Lehrach, H., Klose, J., Gangadharan, U. and Brown, S., (1994). Towards high resolution maps of the mouse and human genomes?a facility for ordering markers to 0.1 cM resolution. Human Molecular Genetics. 3 (4), 621-627

A.Jones, K., M.Black, D., A.Brown, M., L.Griffiths, B., M.Nicolai, H., A.Chambers, J., Bonjardim, M., Xu, C-F., Boyd, M., MeFariane, R., Korn, B., Poustka, A., A.North, M., Schalkwyk, L., Lehrach, H. and Solomon, E., (1994). The detailed characterisation of a 400 kb cosmid walk in the BRCA1 region: identification and localisation of 10 genes including a dual-specificity phosphatase. Human Molecular Genetics. 3 (11), 1927-1934

Jones, JE., Huckaby, CS., Stafford, MD. and Linnoila, RI., (1994). An MspI RFLP of the human AHR gene.. Human molecular genetics. 3 (11), 2083-

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Hoheisel, J., (1993). High resolution cosmid and P1 maps spanning the 14 Mb genome of the fission yeast S. pombe. Cell. 73 (1), 109-120

Schalkwyk, LC., Charlebois, RL. and Doolittle, WF., (1993). Insertion sequences on plasmid pHV1 of Haloferax volcanii. Canadian Journal of Microbiology. 39 (2), 201-206

Schalkwyk, LC., (1993). Chapter 15 Halobacterial genes and genomes. New Comprehensive Biochemistry. 26 (C), 467-496

Cohen, A., Lam, WL., Charlebois, RL., Doolittle, WF. and Schalkwyk, LC., (1992). Localizing genes on the map of the genome of Haloferax volcanii, one of the Archaea.. Proceedings of the National Academy of Sciences. 89 (5), 1602-1606

Doolittle, WF., Lam, WL., Schalkwyk, LC., Charlebois, RL., Cline, SW. and Cohen, A., (1992). Progress in developing the genetics of the halobacteria.. Biochemical Society symposium. 58 (58), 73-78

Charlebois, RL., Schalkwyk, LC., Hofman, JD. and Doolittle, WF., (1991). Detailed physical map and set of overlapping clones covering the genome of the archaebacterium Haloferax volcanii DS2. Journal of Molecular Biology. 222 (3), 509-524

Charlebois, RL., Hofman, JD., Schalkwyk, LC., Lam, WL. and Doolittle, WF., (1989). Genome mapping in halobacteria. Canadian Journal of Microbiology. 35 (1), 21-29

Cline, SW., Schalkwyk, LC. and Doolittle, WF., (1989). Transformation of the archaebacterium Halobacterium volcanii with genomic DNA. Journal of Bacteriology. 171 (9), 4987-4991

Cline, SW., Lam, WL., Charlebois, RL., Schalkwyk, LC. and Doolittle, WF., (1989). Transformation methods for halophilic archaebacteria. Canadian Journal of Microbiology. 35 (1), 148-152

Hofman, JD., Schalkwyk, LC. and Doolittle, WF., (1986). ISH51: a large, degenerate family of insertion sequence-like elements in the genome of the archaehacterium,Halobacterium volcanii. Nucleic Acids Research. 14 (17), 6983-7000

Hannon, E., Dempster, E., Burrage, J., Curtis, C., Gillespie, A., Dempster, D., Gunasinghe, C., Schalkwyk, L., Gaughran, F., Murray, R., Di Forti, M., Collier, D., Breen, G. and Mill, J., (2017). AN EPIGENOME-WIDE ASSOCIATION STUDY OF CLOZAPINE USE IN TREATMENT-RESISTANT SCHIZOPHRENIA

Rutten, B., Vermetten, E., Vinkers, C., Pishva, E., Kenis, G., de Nijs, L., Eijssen, L., Viechtbauer, W., van den Hove, D., Schraut, K., Lesch, K-P., Daskalakis, N., Yehuda, R., Schalkwyk, L., Lunnon, K., Mill, J., Nievergelt, C., Baker, DS., Geuze, E. and Boks, MPM., (2015). Blood-based DNA Methylation Signatures of Susceptibility to Traumatic Stress; Results From A Dutch Prospective Military Cohort Study

Spiers, H., Bray, NJ., Hannon, E., Schalkwyk, LC., Wong, CC., Pidsley, R., Smith, RG. and Mill, J., (2015). ISDN2014_0171: Dynamic and sex‐specific changes in DNA methylation during human fetal brain development

Boks, MPM., van Mierlo, H., Rutten, BPF., Radstake, TRDJ., De Witte, LD., Geuze, E., Horvath, S., Schalkwyk, LC., Vinkers, CH., Broen, JCA. and Vermetten, E., (2015). Longitudinal Changes of Telomere Length and Epigenetic Age Related to Traumatic Stress and Post-traumatic Stress Disorder

Powell, TR., Schalkwyk, LC., Breen, G., Lawrence, T., Pariante, C., McGuffin, P., Tansey, K., Uher, R. and D'Souza, UM., (2012). Identifying transcriptomic biomarkers for response to escitalopram in the inflammatory cytokine pathway

Kõks, S., Velthut, A., Sarapik, A., Altmäe, S., Reinmaa, E., Schalkwyk, LC., Fernandes, C., Lad, H., Soomets, U., Jaakma, ÜW. and Salumets, A., (2011). 166 THE DIFFERENTIAL TRANSCRIPTOME AND ONTOLOGY PROFILES OF MURAL AND CUMULUS GRANULOSA CELLS IN STIMULATED HUMAN ANTRAL FOLLICLES

Sikk, K., Koks, S., Soomets, U., Schalkwyk, LC., Fernandes, C., Haldre, S., Aquilonius, S-M. and Taba, P., (2010). Peripheral blood RNA gene expression profiling in illicit methcathinone users reveals effect on immune system

Amos-Landgraf, J. and Schalkwyk, LC., (2008). The 21st International Mammalian Genome Conference Meeting Report

Meaburn, E., Harlaar, N., Craig, IW., Schalkwyk, LC. and Plomin, R., (2007). Genomewide gene expression profiles as a biological basis for non-shared environment: MZ twins discordant for reading ability

Binder, E., Paya-Cano, JL., Sluyter, F. and Schalkwyk, LC., (2006). P.1.d.016 The effects of a selective serotonin reuptake inhibitor and a tricyclic antidepressant on the behaviour of chronically stressed 129SvemJ and C57BL/6J mice in the hole board and forced swim test

Paya-Cano, JL., Sluyter, F., Mineur, YS., Fernandes, C., Crusio, WE. and Schalkwyk, LC., (2006). P.1.a.015 Strain differences in susceptibility to unpredictable chronic mild stress as assessed by hippocampal gene expression profiling

Meaburn, E., Butcher, LM., Harlaar, N., Curtis, C., Craig, IW., Schalkwyk, LC. and Plomin, R., (2006). An association scan using pooled DNA and 100k SNPS identifies a 'SNP set' for early reading

Huezo-Diaz, P., Williamson, R., Nash, MW., Sim, SC., Alhberg, S., Hoda, F., Rietschel, M., Schmal, C., Farmer, A., Schulze, T., Hauser, J., Henigsberg, N., Maier, W., Zobel, A., Larsen, ER., Mors, O., Mendelewicz, J., Marusic, A., Perez, J., Schalkwyk, L., McGuffin, P., Craig, I., Ingelman-Sundberg, M. and Aitchison, KJ., (2006). CYP2D6 and CYP2C19 association data from GENDEP, a multicentre European study

D'Souza, UM., Sugden, K., Pariante, CM., Byers, H., Ward, M., Schalkwyk, LC., McGuffin, P. and Aitchison, KJ., (2006). Effects of antidepressant treatment on gene expression in mouse cultured cells

Butcher, LM., Meaburn, EL., Craig, IW., Schalkwyk, LC. and Plomin, R., (2006). A genomewide association scan for GE interplay in childhood

D'Souza, UM., Sugden, K., Pariante, CM., Byers, H., Ward, M., Schalkwyk, LC., McGuffin, P. and Aitchison, KJ., (2006). Effects of antidepressant treatment on gene expression in mouse cultured cells

Liu, L., Fernandes, C., Brookes, K., Paya-Capo, J., Asherson, P. and Schalkwyk, LC., (2005). P.2.07 Selecting over-active extremes in outbred heterogeneous stock (HS) mice for gene expression profiling: nominating novel candidate genes for over-activity

Meaburn, EL., Butcher, LM., Knight, J., Craig, I., Schalkwyk, LC. and Plomin, R., (2005). QTLs for reading disability at 7 years: Genotyping pooled DNA on 100K SNP microarrays

Butcher, LM., Meaburn, E., Knight, J., Sham, PC., Schalkwyk, LC., Craig, IW. and Plomin, R., (2005). SNPs, microarrays, and pooled DNA: Identification of four loci associated with mild mental impairment in a sample of 6000 children

Butcher, LM., Meaburn, E., Knight, J., Sham, PC., Schalkwyk, LC., Craig, IW. and Plomin, R., (2005). Allelotyping over 10,000 SNPs using DNA pools and microarrays nominates four SNPs associated with mild mental impairment

Sugden, K., D'Souza, UM., McGuffin, P., Schalkwyk, LC., Aitchison, KJ. and Pariante, CM., (2005). Gene expression analyses of a mouse fibroblast cell line after antidepressant treatment

Fernandes, C., Liu, L., Paya-Cano, JL., Whatley, SA. and Schalkwyk, LC., (2004). Correlating behaviour with gene expression: Identifying genes for anxiety and cognition in the mouse.

Meaburn, EL., Butcher, ML., Liu, L., Fernandes, C., Sham, P., Plomin, R., Craig, I. and Schalkwyk, L., (2004). DNA pools on 10K genechips: Solving the QTL problem of large samples and large numbers of SNPS

Chamberlain, S., Bizarro, L., Fernandes, C., Schalkwyk, L. and Stolerman, IP., (2003). Nicotinic receptors containing the alpha7 subunit do not contribute to nicotine discrimination

Sluyter, F. and Schalkwyk, LC., (2003). Symposium: Using microarrays in the analysis of behavior

Fernandes, C., Paya-Cano, J., Sluyter, F., D'Souza, U., Plomin, R. and Schalkwyk, LC., (2003). The power of gene expression profiling and mouse models to unravel behavior.

Meaburn, E., Schalkwyk, L., Criag, I. and Plomin, R., (2003). A genome wide scan using 400 non-synonymous SNP markers in DNA pools identifies genes associated with language impairment in children

Meaburn, EK., Butcher, LM., Schalkwyk, L., Craig, I. and Plomin, R., (2002). Localisation of quantitative trait loci responsible for the heritability of language impairment using DNA pooling

Hill, L., Meaburn, E., Butcher, LM., Schalkwyk, L., Craig, IW. and Plomin, R., (2002). A genome scan using non-synonymous SNPs in coding regions and general cognitive ability

Galsworthy, MJ., Paya-Cano, JL., Liu, L., Fernandes, C., Schalkwyk, L. and Plomin, R., (2002). The reliabilities, interrelationships and quantitative genetics of cognitive tasks in mus musculus: A study of 250 heterogeneous stock mice

Tandon, K., Schalkwyk, L., Patel, M., Kinirons, M., Kerwin, R., McGuffin, P. and Aitchison, KJ., (2002). An amino acid substitution (IIe109Val) in CYP2D6

Tandon, K., Schalkwyk, LC., Checkley, S., Patel, M., Kinirons, M., Kerwin, RW., McGuffin, P. and Aitchison, KJ., (2002). CYP2D6 genotype and treatment with tricyclic antidepressants

Butcher, LM., Meaburn, EL., Hill, L., Plomin, R. and Schalkwyk, L., (2002). How many non-synonymous SNPS are available on public databases?

Tandon, K., Schalkwyk, L., Checkley, S., Patel, M., Kinirons, M., Kerwin, RW., McGuffin, P. and Aitchison, KJ., (2002). CYP2D6 genotype and treatment with tricyclic antidepressants

Meaburn, EL., Plomin, R. and Schalkwyk, L., (2001). Single nucleotide polymorphism genotyping in DNA pools.

Vettakkorumakankav, NN., Stevenson, KJ., Schalkwyk, LC. and Doolittle, WF., (1994). Disruption of the gene coding for dihydrolipoamide dehydrogenase in Haloferax volcanii by homologous recombination.

ROSS, MT., KNIGHTS, CJ., ROEST CROLLIUS, H., LABELLA, T., HOLLOWAY, E., MIFSUD, J., LI, K., LAM, V., VATCHEVA, R., KUMLEIN, J., FRANCIS, F., MOTT, R., SCHALKWYK, L., BHOGAL, R., ZEHETNER, G. and LEHRACH, H., (1993). BUILDING AN INTEGRATED PHYSICAL AND GENETIC-MAP OF THE HUMAN X-CHROMOSOME

DOOLITTLE, WF., CHARLEBOIS, RL., SCHALKWYK, LC., LAM, WL., CONOVER, RK., TSOULUHAS, D., CLINE, SW., HOFMAN, JD. and COHEN, A., (1991). PHYSICAL MAPPING AND GENE-TRANSFER METHODS FOR HALOBACTERIUM (HALOFERAX) VOLCANII

Hannon, E., Dempster, E., Mansell, G., Schalkwyk, L., Murray, R., McQuillin, A., Kowalec, K., Clair, DS., Morris, D., Sullivan, P., O'Donovan, M., MacCabe, J., Collier, D. and Mill, J., (2019).57METHYLOMIC BIOMARKERS OF SCHIZOPHRENIA AND ANTIPSYCHOTIC MEDICATION EXPOSURE. European Neuropsychopharmacology. 29,Elsevier BV

O'Brien, H., Hannon, E., Hill, M., Toste, C., Robertson, M., Morgan, J., McLaughlin, G., Lewis, C., Schalkwyk, L., Pardinas, A., Owen, M., O'Donovan, M., Mill, J. and Bray, N., (2019).55EXPRESSION QUANTITATIVE TRAIT LOCI IN THE DEVELOPING HUMAN BRAIN AND THEIR ENRICHMENT IN NEUROPSYCHIATRIC DISORDERS. European Neuropsychopharmacology. 29,Elsevier BV

Richmond, RC., Bao, Y., Smart, M., Gorrie-Stone, T., Schalkwyk, L., Mill, J., Davey Smith, G., Benzeval, M., Relton, C. and Kumari, M., (2018).P8 Investigating epigenetic differences in response to shift work: findings fromunderstanding society(UK longitudinal household survey). Poster presentations. 72,BMJ Publishing Group Ltd

Hannon, E., Lunnon, K., Schalkwyk, L. and Mill, J., (2017).CHARACTERIZING INTER-INDIVIDUAL VARIATION IN DNA METHYLATION BETWEEN BLOOD AND BRAIN: IMPLICATIONS FOR EPIGENETIC STUDIES OF PSYCHIATRIC PHENOTYPES. EUROPEAN NEUROPSYCHOPHARMACOLOGY. 27

Hannon, E., Spiers, H., Viana, J., Pidsley, R., Burrage, J., Murphy, T., Troakes, C., Turecki, G., O'Donovan, M., Schalkwyk, L., Bray, NJ. and Mill, J., (2017).METHYLATION QUANTITATIVE TRAIT LOCI (MQTL) IN THE DEVELOPING HUMAN BRAIN AND THEIR ENRICHMENT IN GENOMIC REGIONS ASSOCIATED WITH SCHIZOPHRENIA. EUROPEAN NEUROPSYCHOPHARMACOLOGY. 27

Viana, J., Pidsley, R., Hannon, E., Spiers, H., Troakes, C., Al-Saraj, S., Mechawar, N., Turecki, G., Schalkwyk, L., Bray, NJ. and Mill, J., (2017).INVESTIGATING EPIGENOMIC REGULATION IN SCHIZOPHRENIA. EUROPEAN NEUROPSYCHOPHARMACOLOGY. 27

Xia, B., Kepa, A., Colvert, E., Mea-burn, E., Ronald, A., Schalkwyk, L., Mill, J., Plomin, R., Happe, F. and Wong, CCY., (2017).AN INVESTIGATION OF X-CHROMOSOME INACTIVATION PROFILES USING A GENETICALLY SENSITIVE DISCORDANT TWIN DESIGN. EUROPEAN NEUROPSYCHOPHARMACOLOGY. 27

Hannon, E., Dempster, E., Burrage, J., Smith, A., Gurling, H., Basso, N., McQuillin, A., Schalkwyk, L. and Mill, J., (2017).AN INTEGRATED GENETIC-EPIGENETIC ANALYSIS OF SCHIZOPHRENIA. EUROPEAN NEUROPSYCHOPHARMACOLOGY. 27

Dempster, E., Hannon, E., Schalkwyk, L., Bohlken, M., Kaprio, J., Toulopoulou, T., Spector, T., Hulshoffpol, H., Nenadic, I., Cannon, T., Hultman, C., Murray, R. and Mill, J., (2017).GENOME-WIDE METHYLOMIC ANALYSIS OF MONOZYGOTIC TWINS DISCORDANT FOR SCHIZOPHRENIA. EUROPEAN NEUROPSYCHOPHARMACOLOGY. 27

Wong, CCY., Parikshak, N., Spiers, H., Brays, NJ., Lysenko, L., Troakes, C., Viana, J., Hannon, E., Schalkwyk, L., Geschwind, D. and Mill, J., (2017).METHYLOMIC ANALYSIS OF AUTISM BRAIN: DISEASE ASSOCIATED VARIATION AND SUPPORT FOR A NEURODEVELOPMENTAL COMPONENT TO ETIOLOGY. EUROPEAN NEUROPSYCHOPHARMACOLOGY. 27

Spiers, H., Hannon, E., Schalkwyk, L., Bray, N. and Mill, J., (2017).DNA HYDROXYMETHYLATION ASSOCIATED WITH HUMAN FETAL BRAIN DEVELOPMENT. EUROPEAN NEUROPSYCHOPHARMACOLOGY. 27