People

Dr Vlad Teif

Senior Lecturer
School of Life Sciences
Dr Vlad Teif
  • Email

  • Telephone

    +44 (0) 1206 872121

  • Location

    3SW.5.25, Colchester Campus

Profile

Biography

Our lab works on fundamental and translational aspects of gene regulation in ageing, cancer and cell differentiation using approaches of biophysics, bioinformatics and next generation sequencing. On the fundamental side, our focus is on nucleosome positioning and transcription factor-nucleosome interaction. On the translational side, our focus is on liquid biopsied based on cell-free DNA for patient diagnostics, stratification and monitoring.

Qualifications

  • Fellow of Higher Education Academy (FHEA) University of Essex,

  • PhD CEA/Saclay and IBOCH NASB,

  • MSc Belarusian State Unversity,

Appointments

University of Essex

  • Senior Lecturer, School of Life Sciences, University of Essex (1/10/2021 - present)

  • Lecturer, School of Life Sciences, University of Essex (1/5/2015 - present)

Other academic

  • Researcher, German Cancer Research Center (DKFZ) (1/9/2009 - 30/4/2015)

  • Senior Researcher, National Academy of Sciences of Belarus (1/6/2009 - 1/6/2010)

  • Visiting Scientist, University of California, San Diego (1/2/2008 - 1/6/2008)

  • Visiting Scientist, Hebrew University of Jerusalem (1/11/2005 - 29/5/2007)

  • Researcher, National Academy of Sciences of Belarus (1/6/2004 - 1/6/2009)

Research and professional activities

Research interests

Modelling gene regulation

Modelling gene regulation in chromatin

Key words: gene regulation
Open to supervise

Cancer epigenetics

Studying epigenetic effects in cancer

Key words: cancer
Open to supervise

Stem cell differentiation

Computational modelling of cell differentiation

Key words: differentiation
Open to supervise

Nucleosome positioning

Key words: nucleosome
Open to supervise

Transcription factor binding

Transcription factor-focused description of gene regulation

Key words: TF
Open to supervise

Liquid biopsies based on cell-free DNA

Key words: cfDNA
Open to supervise

Augmented reality tools for education and science outreach

Development of augmented reality tools for education and science outreach

Key words: AR

Teaching and supervision

Current teaching responsibilities

  • Transferable Skills in Life Sciences (BS143)

  • Employability Skills for the Biosciences (BS211)

  • Genome Science (BS222)

  • Genome Bioinformatics (BS312)

  • Molecular Basis of Cancer (BS349)

  • Advanced Cancer Biology (BS932)

Previous supervision

Isabella Ciuta
Isabella Ciuta
Thesis title: Chromatin Reorganisation and Differential Transcription Factor Binding in Breast Cancer
Degree subject: Molecular Medicine
Degree type: Master of Science (by Dissertation)
Awarded date: 20/5/2024
Clark Ezekiel Oruga Correa
Clark Ezekiel Oruga Correa
Thesis title: Nucleosome Repositioning in Glioblastoma Multiforme
Degree subject: Molecular Medicine
Degree type: Master of Science (by Dissertation)
Awarded date: 8/5/2024
Anne-Marie Tricolici
Anne-Marie Tricolici
Thesis title: Investigation of Mtor-Dependant Neuronal Markers, Gene Expression, and Central Metabolism in Dopaminergic Neurons.
Degree subject: Cell and Molecular Biology
Degree type: Master of Science (by Dissertation)
Awarded date: 29/4/2024
Divya Rose Jacob
Divya Rose Jacob
Thesis title: Nucleosome Repositioning in Breast Cancer
Degree subject: Biological Sciences
Degree type: Master of Science (by Dissertation)
Awarded date: 24/4/2023
Mariya Shtumpf
Mariya Shtumpf
Thesis title: Nucleosomics Analysis of Cell-Free Dna for Patient Stratification
Degree subject: Molecular Medicine
Degree type: Master of Science (by Dissertation)
Awarded date: 2/3/2023
Varvara Koraki Folli
Varvara Koraki Folli
Thesis title: Nucleosome Repositioning in Glioblastoma
Degree subject: Molecular Medicine
Degree type: Master of Science (by Dissertation)
Awarded date: 19/4/2021
Christopher Thomas Clarkson
Christopher Thomas Clarkson
Thesis title: Changes of Nucleosome Positioning and 3D Chromatin Organisation in Cell Differentiation and Cancer
Degree subject: Cell and Molecular Biology
Degree type: Doctor of Philosophy
Awarded date: 31/3/2020

Publications

Publications (2)

Takahashi, N., Pongor, L., Agrawal, SP., Shtumpf, M., Rajapakse, VN., Shafiei, A., Schultz, CW., Kim, S., Roame, D., Carter, P., Vilimas, R., Nichols, S., Desai, P., Figg, WD., Bagheri, M., Teif, VB. and Thomas, A., (2024). Genomic alterations and transcriptional phenotypes in circulating tumor DNA and matched metastatic tumor

Tajmul, M., Bhatt, DN., Ruje, L., Price, E., Ji, Y., Loukinov, D., Teif, VB., Lobanenkov, VV. and Pugacheva, EM., (2024). CTCF binding landscape is established by the epigenetic status of the nucleosome, well-positioned relative to CTCF motif orientation

Journal articles (52)

Peng, Y., Song, W., Teif, VB., Ovcharenko, I., Landsman, D. and Panchenko, AR., Detection of new pioneer transcription factors as cell-type-specific nucleosome binders. eLife. 12

Jacob, DR., Guiblet, WM., Mamayusupova, H., Shtumpf, M., Ciuta, I., Ruje, L., Gretton, S., Bikova, M., Correa, C., Dellow, E., Agrawal, SP., Shafiei, N., Drobysevskaja, A., Armstrong, CM., Lam, JDG., Vainshtein, Y., Clarkson, CT., Thorn, GJ., Sohn, K., Pradeepa, MM., Chandrasekharan, S., Brooke, GN., Klenova, E., Zhurkin, VB. and Teif, VB., (2024). Nucleosome reorganisation in breast cancer tissues.. Clinical Epigenetics. 16 (1), 50-

Teif, V., Peng, Y., Song, W., Ovcharenko, I., Landsman, D. and Panchenko, A., (2024). Detection of new pioneer transcription factors as cell-type specific nucleosome binders. eLife. 12, RP88936-

Shtumpf, M., Jeong, S., Bikova, M., Mamayusupova, H., Ruje, L. and Teif, VB., (2024). Aging clock based on nucleosome reorganisation derived from cell-free DNA.. Aging Cell. 23 (5), e14100-

Gautam, P., Ciuta, I., Teif, VB. and Sinha, SK., (2024). Predicting p53-dependent cell transitions from thermodynamic models. The Journal of Chemical Physics. 161 (13), 135101-

Piroeva, KV., McDonald, C., Xanthopoulos, C., Fox, C., Clarkson, CT., Mallm, J-P., Vainshtein, Y., Ruje, L., Klett, LC., Stilgenbauer, S., Mertens, D., Kostareli, E., Rippe, K. and Teif, VB., (2023). Nucleosome repositioning in chronic lymphocytic leukemia. Genome Research. 33 (10), 1649-1661

Shtumpf, M., Piroeva, KV., Agrawal, SP., Jacob, DR. and Teif, VB., (2022). NucPosDB: a database of nucleosome positioning in vivo and nucleosomics of cell-free DNA. Chromosoma. 131 (1-2), 19-28

Thorn, GJ., Clarkson, CT., Rademacher, A., Mamayusupova, H., Schotta, G., Rippe, K. and Teif, VB., (2022). DNA sequence-dependent formation of heterochromatin nanodomains.. Nature Communications. 13 (1), 1861-

Belokopytova, P., Viesná, E., Chiliński, M., Qi, Y., Salari, H., Di Stefano, M., Esposito, A., Conte, M., Chiariello, AM., Teif, VB., Plewczynski, D., Zhang, B., Jost, D. and Fishman, V., (2022). 3DGenBench: a web-server to benchmark computational models for 3D Genomics. Nucleic Acids Research. 50 (W1), W4-W12

Cucinotta, CE., Martin, BJE., Noé González, M., Raman, P., Teif, VB. and Vlaming, H., (2021). Strength is in engagement The rise of an online scientific community during the COVID‐19 pandemic. EMBO Reports. 22 (5), e52612-

Hedley, JG., Teif, VB. and Kornyshev, AA., (2021). Nucleosome-induced homology recognition in chromatin. Journal of The Royal Society Interface. 18 (179), 20210147-20210147

Mohr, A., Chu, T., Clarkson, C., Brooke, G., Teif, V. and Zwacka, R., (2021). Fas-threshold Signalling in MSCs Promotes Pancreatic Cancer Progression and Metastasis. Cancer Letters. 519, 63-77

Antwi, EB., Olins, A., Teif, VB., Bieg, M., Bauer, T., Gu, Z., Brors, B., Eils, R., Olins, D. and Ishaque, N., (2020). Whole-genome fingerprint of the DNA methylome during chemically induced differentiation of the human AML cell line HL-60/S4. Biology Open. 9 (2), bio044222-

Teif, V., (2020). Soft power of non-consensus protein-DNA binding. Biophysical Journal. 118 (8), 1797-1798

Teif, V., Gould, T., Clarkson, C., Boyd, L., Antwi, E., Ishaque, N., Olins, A. and Olins, D., (2020). Linker histone epitopes are hidden by in situ higher-order chromatin structure. Epigenetics and Chromatin. 13 (1), 26-

Antwi, EB., Olins, A., Teif, VB., Bieg, M., Bauer, T., Gu, Z., Brors, B., Eils, R., Olins, D. and Ishaque, N., (2020). Whole-genome fingerprint of the DNA methylome during chemically induced differentiation of the human AML cell line HL-60/S4.. Biology open

Wiehle, L., Thorn, G., Raddatz, G., Clarkson, C., Rippe, K., Lyko, F., Breiling, A. and Teif, V., (2019). DNA (de)methylation in embryonic stem cells controls CTCF-dependent chromatin boundaries. Genome Research. 29 (5), 750-761

Mallm, JP., Iskar, M., Ishaque, N., Klett, LC., Kugler, SJ., Muino, JM., Teif, VB., Poos, AM., Großmann, S., Erdel, F., Tavernari, D., Koser, SD., Schumacher, S., Brors, B., König, R., Remondini, D., Vingron, M., Stilgenbauer, S., Lichter, P., Zapatka, M., Mertens, D. and Rippe, K., (2019). Linking aberrant chromatin features in chronic lymphocytic leukemia to transcription factor networks. Molecular Systems Biology. 15 (5), e8339-

Clarkson, CT., Deeks, EA., Samarista, R., Mamayusupova, H., Zhurkin, VB. and Teif, VB., (2019). CTCF-dependent chromatin boundaries formed by asymmetric nucleosome arrays with decreased linker length. Nucleic Acids Research. 47 (21), 11181-11196

Pavlaki, I., Docquier, F., Chernukhin, I., Kita, G., Gretton, S., Clarkson, CT., Teif, VB. and Klenova, E., (2018). Poly(ADP-ribosyl)ation associated changes in CTCF-chromatin binding and gene expression in breast cells. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1861 (8), 781-730

Vainshtein, Y., Rippe, K. and Teif, VB., (2017). NucTools: analysis of chromatin feature occupancy profiles from high-throughput sequencing data. BMC Genomics. 18 (1), 158-

Teif, VB., Mallm, J-P., Sharma, T., Mark Welch, DB., Rippe, K., Eils, R., Langowski, J., Olins, AL. and Olins, DE., (2017). Nucleosome repositioning during differentiation of a human myeloid leukemia cell line. Nucleus. 8 (2), 188-204

Teif, VB., (2016). Nucleosome positioning: resources and tools online. Briefings in Bioinformatics. 17 (5), 745-757

B. Teif, V. and G. Cherstvy, A., (2016). Chromatin and epigenetics: current biophysical views. AIMS Biophysics. 3 (1), 88-98

Salih, BF., Teif, VB., Tripathi, V. and Trifonov, EN., (2015). Strong nucleosomes of mouse genome including recovered centromeric sequences. Journal of Biomolecular Structure and Dynamics. 33 (6), 1164-1175

Teif, VB., Kepper, N., Yserentant, K., Wedemann, G. and Rippe, K., (2015). Affinity, stoichiometry and cooperativity of heterochromatin protein 1 (HP1) binding to nucleosomal arrays. Journal of Physics: Condensed Matter. 27 (6), 064110-064110

Cherstvy, AG. and Teif, VB., (2014). Electrostatic effect of H1-histone protein binding on nucleosome repeat length. Physical Biology. 11 (4), 044001-044001

Beshnova, DA., Cherstvy, AG., Vainshtein, Y. and Teif, VB., (2014). Regulation of the nucleosome repeat length in vivo by the DNA sequence, protein concentrations and long-range interactions.. PLoS Computational Biology. 10 (7), e1003698-e1003698

Teif, VB., Beshnova, DA., Vainshtein, Y., Marth, C., Mallm, J-P., Höfer, T. and Rippe, K., (2014). Nucleosome repositioning links DNA (de)methylation and differential CTCF binding during stem cell development. Genome Research. 24 (8), 1285-1295

Diermeier, S., Kolovos, P., Heizinger, L., Schwartz, U., Georgomanolis, T., Zirkel, A., Wedemann, G., Grosveld, F., Knoch, TA., Merkl, R., Cook, PR., Längst, G. and Papantonis, A., (2014). TNFα signalling primes chromatin for NF-κB binding and induces rapid and widespread nucleosome repositioning. Genome Biology. 15 (12), 536-

Schöpflin, R., Teif, VB., Müller, O., Weinberg, C., Rippe, K. and Wedemann, G., (2013). Modeling nucleosome position distributions from experimental nucleosome positioning maps. Bioinformatics. 29 (19), 2380-2386

Teif, VB., Erdel, F., Beshnova, DA., Vainshtein, Y., Mallm, JP. and Rippe, K., (2013). Taking into account nucleosomes for predicting gene expression. Methods. 62 (1), 26-38

Cherstvy, AG. and Teif, VB., (2013). Structure-driven homology pairing of chromatin fibers: the role of electrostatics and protein-induced bridging. Journal of Biological Physics. 39 (3), 363-385

Teif, VB., Vainshtein, Y., Caudron-Herger, M., Mallm, J-P., Marth, C., Höfer, T. and Rippe, K., (2012). Genome-wide nucleosome positioning during embryonic stem cell development. Nature Structural & Molecular Biology. 19 (11), 1185-1192

Teǐf, VB., Shkrobkov, AV., Egorova, VP. and Krot, VI., (2012). [Nucleosomes in gene regulation: theoretical approaches].. Molekuliarnaia biologiia. 46 (1), 3-13

Teif, VB. and Rippe, K., (2012). Calculating transcription factor binding maps for chromatin. Briefings in Bioinformatics. 13 (2), 187-201

Teif, VB., Shkrabkou, AV., Egorova, VP. and Krot, VI., (2012). Nucleosomes in gene regulation: Theoretical approaches. Molecular Biology. 46 (1), 1-10

Teif, VB. and Bohinc, K., (2011). Condensed DNA: Condensing the concepts. Progress in Biophysics and Molecular Biology. 105 (3), 208-222

Teif, VB. and Rippe, K., (2011). Nucleosome mediated crosstalk between transcription factors at eukaryotic enhancers. Physical Biology. 8 (4), 044001-044001

Teif, VB. and Rippe, K., (2010). Statistical-mechanical lattice models for protein-DNA binding in chromatin. Journal of Physics: Condensed Matter. 22 (41), 414105-414105

Teif, VB., (2010). Predicting Gene-Regulation Functions: Lessons from Temperate Bacteriophages. Biophysical Journal. 98 (7), 1247-1256

Teif, VB., Ettig, R. and Rippe, K., (2010). A Lattice Model for Transcription Factor Access to Nucleosomal DNA. Biophysical Journal. 99 (8), 2597-2607

Teif, VB. and Rippe, K., (2009). Predicting nucleosome positions on the DNA: combining intrinsic sequence preferences and remodeler activities. Nucleic Acids Research. 37 (17), 5641-5655

Teif, VB., Harries, D., Lando, DY. and Ben‐Shaul, A., (2008). Matrix formalism for site‐specific binding of unstructured proteins to multicomponent lipid membranes. Journal of Peptide Science. 14 (4), 368-373

Teif, VB., Harries, D., Lando, DY. and Ben-Shaul, A., (2008). Matrix formalism for site-specific binding of unstructured proteins to multicomponent lipid membranes. JOURNAL OF PEPTIDE SCIENCE. 14 (4), 368-373

Teif, VB., (2007). General transfer matrix formalism to calculate DNA–protein–drug binding in gene regulation: application to O R operator of phage λ. Nucleic Acids Research. 35 (11), e80-e80

Teif, VB., (2005). Ligand-Induced DNA Condensation: Choosing the Model. Biophysical Journal. 89 (4), 2574-2587

Teif, VB., Haroutiunian, SG., Vorob'ev, VI., Lando, DY. and Ivanov, V., (2002). Short-Range Interactions and Size of Ligands Bound to DNA Strongly Influence Adsorptive Phase Transition Caused by Long-Range Interactions. Journal of Biomolecular Structure and Dynamics. 19 (6), 1093-1100

Lando, DY. and Teif, VB., (2002). Modeling of DNA Condensation and Decondensation Caused by Ligand Binding. Journal of Biomolecular Structure and Dynamics. 20 (2), 215-222

Teif, VB. and Yu Lando, D., (2001). Calculations of DNA condensation caused by ligand adsorption. Molekulyarnaya Biologiya. 35 (1), 117-119

Teif, VB. and Lando, DY., (2001). Calculations of DNA condensation caused by ligand adsorption. Molecular Biology. 35 (1), 106-107

Lando, DY. and Teif, VB., (2000). Long-Range Interactions between Ligands Bound to a DNA Molecule Give Rise to Adsorption with the Character of Phase Transition of the First Kind. Journal of Biomolecular Structure and Dynamics. 17 (5), 903-911

Book chapters (4)

Teif, VB. and Clarkson, CT., (2019). Nucleosome positioning. In: Encyclopedia of Bioinformatics and Computational Biology (vol 2). Editors: Ranganathan, S., Gribskov, M., Nakai, K. and Schönbach, C., . Elsevier. 308- 317. 978-0-12-811432-2

Teif, VB., (2014). On the Sociology of Science 2.0. In: Opening Science. Springer International Publishing. 309- 311. 9783319000251

Längst, G., Teif, VB. and Rippe, K., (2011). Chromatin Remodeling and Nucleosome Positioning. In: Genome Organization and Function in the Cell Nucleus. Wiley. 111- 138. 9783527326983

Teif, VB. and Lando, DY., (2001). DNA Condensation Caused by Ligand Binding May Serve as a Sensor. In: Sensor Technology 2001. Springer Netherlands. 155- 160. 9789401038416

Conferences (13)

Teif, VB., Beshnova, DA., Vainshtein, Y., Höfer, T. and Rippe, K., Developing a software suite to analyze the interplay between nucleosome arrangement, DNA methylation and transcription factor binding

Xanthopoulos, C., McDonald, C., Crawford, L., Teif, V., Ray-Jones, H., Spilakov, M., Roue, G., Mills, K. and Kostareli, E., (2023). TRIM24 expression and regulation in chronic lymphocytic leukaemia upon BTK inhibition

Kagansky, A., Gulaia, V., Tiasto, V., Mikhailova, V., Thoms, H., Burton, J., Yurchenko, A., Guschin, D., Brennan, P., Biktimirov, A. and Teif, V., (2019). Analysis of epigenetic perturbations in gliomas

Teif, VB. and Rippe, K., (2015). 8 Interplay of nucleosome repositioning, DNA methylation and transcription factor binding during stem cell development

Schöpflin, R., Müller, O., Weinberg, C., Teif, VB., Rippe, K. and Wedemann, G., (2014). Modeling Effects of Nucleosome Positioning in Short and Long Chromatin Fibers

Teif, V., Beshnova, DA., Vainshtein, Y., Marth, C., Mallm, J-P., Hoefer, T. and Rippe, K., (2014). Nucleosome rearrangement as a feedback mechanism between DNA methylation and transcription factor binding

Schöpflin, R., Teif, VB., Müller, O., Weinberg, C., Rippe, K. and Wedemann, G., (2013). Modeling Long Chromatin Fibers based on In-Vivo Nucleosome Positioning Maps

Beshnova, DA., Rippe, K. and Teif, VB., (2013). A novel method to calculate transcription factor binding in chromatin

Andrianov, AM. and Teif, VB., (2007). 3D structure model for a peptide presenting the immunogenic crown of the HIV-1 GP120 V3 loop

Teif, VB., (2007). General transfer matrix formalism to calculate DNA-protein binding in gene regulation: Applications to the lambda-switch and beyond

Lando, DY., Fridman, AS. and Teif, VB., (2007). Calculation of DNA-ligand binding characterized by the infinite radius of interactions of adsorbed ligands

Teif, V., (2005). Ligand-induced DNA condensation: Theory and experiments

Teif, VB., Vorob'ev, VI. and Lando, DY., (2002). A single DNA chemical modification by cisplatin may cause long-range changes in protein binding to DNA. Results of computer modeling.

Reports and Papers (8)

Shtumpf, M., Piroeva, KV., Agrawal, SP., Jacob, DR. and Teif, VB., (2021). NucPosDB: a database of nucleosome positioning in vivo and nucleosomics of cell-free DNA

Thorn, G., Clarkson, C., Rademacher, A., Mamayusupova, H., Schotta, G., Rippe, K. and Teif, V., (2021). DNA sequence-dependent formation of heterochromatin nanodomains

Hedley, JG., Teif, VB. and Kornyshev, AA., (2021). Nucleosome induced homology recognition in chromatin

Mohr, A., Tianyuan, C., Clarkson, CT., Brooke, GN., Teif, VB. and Zwacka, RM., (2020). Fas-threshold signalling in MSCs causes tumour progression and metastasis

Clarkson, CT., Deeks, EA., Samarista, R., Mamayusupova, H., Zhurkin, VB. and Teif, VB., (2019). CTCF-dependent chromatin boundaries formed by asymmetric nucleosome arrays with decreased linker length

Antwi, EB., Olins, A., Teif, VB., Bieg, M., Bauer, T., Gu, Z., Brors, B., Eils, R., Olins, D. and Ishaque, N., (2019). Whole-genome fingerprint of the DNA methylome during chemically induced differentiation of the human AML cell line HL-60/S4

Pavlaki, I., Docquier, F., Chernukhin, I., Kita, G., Gretton, S., Teif, V. and Klenova, E., (2018). Poly(ADP-ribosyl)ation associated changes in CTCF-chromatin binding and gene expression in breast cells

Teif, VB., (2013). Science 3.0: Corrections to the Science 2.0 paradigm

Grants and funding

2024

Next-generation liquid biopsies for early detection of pancreatic cancer based on cell-free DNA nucleosomics

Pancreatic Cancer UK

2023

Nucleosomics for liquid biopsies

Cancer Research UK

Summer Studentship 2023 - Nucleosome atlas of human ageing - Milena Bikova

Genetics Society

2022

New method of early cancer diagnostics and stratification based on nucleosome positioning reconstructed from cell-free DNA

Cancer Research UK

2021

Integrating cellular space and time: interplays between subcellular organisation and lifespan

Biotechnology and Biological Sciences Research Council

Dynamic landscape of CTCF binding in cellular decision making

Genetics Society

Integrating cellular space and time: interplays between subcellular organisation and lifespan

Biotechnology and Biological Sciences Research Council

2020

Developing new genomic approaches to target COVID-19: focus on cfDNA and antisense strategies

Genetics Society

2019

Genes & Development Summer Studentship

Genetics Society

Cancer, Biophysics, Gene regulation, Epigenetics - Indian Institute of Technology Bombay

University of Essex (GCRF)

Mini-workshop associated with the visit of Prof Ranjith Padinhateeri

University of Essex (GCRF)

2018

Nucleosome Repeat Length (NRL) as an integrative indicator of stem cell differentiation

Wellcome Trust

2016

Nucleosome repositioning as a mechanism for cell memory in cancer transitions

Wellcome Trust

Contact

vteif@essex.ac.uk
+44 (0) 1206 872121

Location:

3SW.5.25, Colchester Campus

More about me
Gene Regulation -- Teif Lab: http://generegulation.org/

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