Protein Structure and Mechanisms of Disease Group

• New research project to identify Black men at increased risk of prostate cancer
• Research offers new hope for lung and bladder cancer patients
• Prostate cancer drugs could help treat COVID-19 patients
• Blood substitute research enters exciting new phase
• Research shows best models to test possible COVID-19 therapies

• Alav, Ilyas and Bavro, Vassiliy N and Blair, Jessica MA (2022) 'A role for the periplasmic adaptor protein AcrA in vetting substrate access to the RND efflux transporter AcrB.' Scientific Reports, 12 (1). 4752-. ISSN 2045-2322
• Chatterjee, Sayanti and Harden, Ingolf and Bistoni, Giovanni and Castillo, Rebeca G and Chabbra, Sonia and van Gastel, Maurice and Schnegg, Alexander and Bill, Eckhard and Birrell, James A and Morandi, Bill and Neese, Frank and DeBeer, Serena (2022) 'A Combined Spectroscopic and Computational Study on the Mechanism of Iron-Catalyzed Aminofunctionalization of Olefins Using Hydroxylamine Derived N-O Reagent as the "Amino" Source and "Oxidant".' Journal of the American Chemical Society, 144 (6). pp. 2637-2656. ISSN 0002-7863
• Furlan, Chris and Chongdar, Nipa and Gupta, Pooja and Lubitz, Wolfgang and Ogata, Hideaki and Blaza, James N and Birrell, James A (2022) 'Structural insight on the mechanism of an electron-bifurcating [FeFe] hydrogenase.' eLife, 11. e79361-. ISSN 2050-084X
• Galderisi, Silvia and Milella, Maria Serena and Rossi, Martina and Cicaloni, Vittoria and Rossi, Ranieri and Giustarini, Daniela and Spiga, Ottavia and Tinti, Laura and Salvini, Laura and Tinti, Cristina and Braconi, Daniela and Millucci, Lia and Lupetti, Pietro and Prischi, Filippo and Bernardini, Giulia and Santucci, Annalisa (2022) 'Homogentisic acid induces autophagy alterations leading to chondroptosis in human chondrocytes: Implications in Alkaptonuria.' Archives of Biochemistry and Biophysics, 717. p. 109137. ISSN 0003-9861
• Lorenzi, Marco and Ceccaldi, Pierre and Rodríguez-Maciá, Patricia and Redman, Holly Jayne and Zamader, Afridi and Birrell, James A and Mészáros, Livia S and Berggren, Gustav (2022) 'Stability of the H-cluster under whole-cell conditions-formation of an Htrans-like state and its reactivity towards oxygen.' Journal of Biological Inorganic Chemistry, 27 (3). pp. 345-355. ISSN 0949-8257
• Moreno-Chicano, Tadeo and Carey, Leiah M and Axford, Danny and Beale, John H and Doak, R Bruce and Duyvesteyn, Helen ME and Ebrahim, Ali and Henning, Robert W and Monteiro, Diana CF and Myles, Dean A and Owada, Shigeki and Sherrell, Darren A and Straw, Megan L and Šrajer, Vukica and Sugimoto, Hiroshi and Tono, Kensuke and Tosha, Takehiko and Tews, Ivo and Trebbin, Martin and Strange, Richard W and Weiss, Kevin L and Worrall, Jonathan AR and Meilleur, Flora and Owen, Robin L and Ghiladi, Reza A and Hough, Michael A (2022) 'Complementarity of neutron, XFEL and synchrotron crystallography for defining the structures of metalloenzymes at room temperature.' IUCrJ, 9 (5). pp. 610-624. ISSN 2052-2525
• Sanchez, Monica LK and Wiley, Seth and Reijerse, Edward and Lubitz, Wolfgang and Birrell, James A and Dyer, R Brian (2022) 'Time-Resolved Infrared Spectroscopy Reveals the pH-Independence of the First Electron Transfer Step in the [FeFe] Hydrogenase Catalytic Cycle.' Journal of Physical Chemistry Letters, 13 (25). pp. 5986-5990. ISSN 1948-7185
• Trampari, Eleftheria and Zhang, Chuanzhen and Gotts, Kathryn and Savva, George and Bavro, Vassiliy and Webber, Mark (2022) 'Cefotaxime Exposure Selects Mutations within the CA-Domain of envZ Which Promote Antibiotic Resistance but Repress Biofilm Formation in Salmonella.' Microbiology Spectrum, 10 (3). e0214521-. ISSN 2165-0497
• Wilson, Michael T and Reeder, Brandon J (2022) 'The peroxidatic activities of Myoglobin and Hemoglobin, their pathological consequences and possible medical interventions.' Molecular Aspects of Medicine, 84. p. 101045. ISSN 0098-2997

Academics and research students in our group have access to a range of equipment and facilities which can be used for their research.

Biomedical EPR Facility

This includes the BBSRC-funded Bruker E500 continuous wave X-band EPR spectrometer, an Oxford Instruments liquid helium system, a bespoke Rapid Freeze-Quench (RFQ) apparatus and more. Please visit the site for more details.

Macromolecular Interactions Facility

This is a dedicated fully open access interdisciplinary facility for studies of protein structure and function using isothermal titration calorimetry (MicroCal ITC200), ÄKTA-Pure SEC-MALS (Cytiva-Agilent), CD (Applied Photophysics Chirascan), CLARIOstar and FLUOstar plate readers (BMG Labtech).

The Facility is also equipped with a Gryphon crystallisation robot, two Leica M125 microscopes.